User talk:Jimbo Wales

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CRISPR Cas9 editing sequence

	Congratulations! You've been awarded your own theoretical CRISPR Cas9 human germline genome editing sequence
	Hey Jimbo, everyone knows how much you helped editing, so I'm awarding you one of my coveted theoretical CRISPR human germline genome edits which might exist some day if you play your cards right. This one cures either ebola or Zika, not sure which. EllenCT (talk) 01:42, 15 July 2018 (UTC)[reply]

Would the peanut gallery please stop asking about the identity of the coveters. Thank you. EllenCT (talk) 09:27, 15 July 2018 (UTC)[reply]

Also, to everyone who topic banned me from economics, you didn't think I'd get into bio, did you? Ha! EllenCT (talk) 09:33, 15 July 2018 (UTC)[reply]

This is a fascinating paper. Brand new procedures like toehold switch RNA sensors and NASBA are worked brilliantly together here, even if Figure 1 looks a bit too much like an ad. But everything in the paper, and from a few control-Fs even in the latest patent, seems to be about finding multiple copies of RNA in something like serum rather than cellular RNA characterization. The extension is obvious, but it may take considerable digging to see how much technical improvement is required to get there. Meanwhile, the patent goes to an even crazier level of technology to do "protein fingerprinting" with molecular crawlers and motors.

One way or another, the gold standard here for the genetics troll is to present the rugby coach in Lesotho or the boxing official in Thailand with a little scrap of paper which, in combination with a drop of clotted blood, can tell him the apolipoprotein E status of the players. If a player tests for E2 or E3, he might be careless with the helmet; if it's E4, he can pack up his stuff and go home ... for good. Doing the test opens a new age of genetic discrimination, while not doing it means that players suffer permanent brain damage and an early death per Concussion (2015 film). (That said, no doubt the patent police would tell the genetic troll what he does is wrong, unless he were the first to do it; an official who refuses to use the test in one case might commit negligence and lose all he has, but a patent owner who neglects to license a disruptive new technology is, of course, blameless; this is an application of the "kill them all and you're a god" principle) Meanwhile, if you're interested in biology, those are some great redlinks to get started on, and you'll have no trouble finding more in the paper, whose PDF is freely downloadable. Wnt (talk) 14:49, 15 July 2018 (UTC)[reply]

Thanks, I'm looking at the general field in relation to the facinating (especially in light of the CRISPR developments) Small interfering RNA article, which the thumbnail is from. EllenCT (talk) 18:16, 15 July 2018 (UTC)[reply]

Brrr

I have an account, but why can’t I still edit protected articles?ColorTheoryRGB (talk) 20:39, 15 July 2018 (UTC)[reply]

See WP:CONFIRM. Looie496 (talk) 21:39, 15 July 2018 (UTC)[reply]