RaTG13
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| BatCoV RaTG13 | |
|---|---|
Virus classification 
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| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Pisuviricota |
| Class: | Pisoniviricetes |
| Order: | Nidovirales |
| Family: | Coronaviridae |
| Genus: | Betacoronavirus |
| Virus: | BatCoV RaTG13
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Bat coronavirus RaTG13 is a betacoronavirus found in 2013 in Yunnan China, that infects the horse shoe bat Rhinolophus affinis.[1] It has a very close genetic relationship with the COVID-19 virus.[2]
This virus is a Positive-strand RNA virus with outer membrane. Its genome is about 29800nt, encoding a replicase (ORF1a/1b), four structural proteins, including spike protein (S), membrane protein (M), outer membrane protein (E) and capsid protein (N), and five helper proteins, including NS3, NS6, ns7a, ns7b and NS8, which are common in coronaviruses.[3]
As of 2020[update]，RaTG13 is the closest virus to SARS-CoV-2 found in nature, with 96% similarity,[4] while SARS-CoV-1 has only about 80% similarity. However, the difference between the two viruses in receptor-binding domain (RBD) of spike protein (S), which is the part that binds to the receptor on the surface of the host cell and causes infection, indicates that RaTG13 virus may not use Angiotensin-converting enzyme 2 (ACE2) as the receptor to enter the cell as SARS-CoV-2.[5] In addition, the S protein of RaTG13 virus does not have PRRA motif which could be cleaved by protease Furin in SARS-CoV-2 infection.[5]
References
- ^ Xiao C, Li X, Liu S, Sang Y, Gao SJ, Gao F (2020). "HIV-1 did not contribute to the 2019-nCoV genome". Emerging Microbes & Infections. 9 (1): 378–381. doi:10.1080/22221751.2020.1727299. PMID 32056509.
- ^ Poudel U, Subedi D, Pantha S, Dhakal S (October 2020). "Animal coronaviruses and coronavirus disease 2019: Lesson for One Health approach". Open Veterinary Journal. 10 (3): 239–251. doi:10.4314/ovj.v10i3.1. PMID 33282694.
- ^ "Bat coronavirus RaTG13, complete genome". NCBI. Retrieved 2020-03-28.
- ^ Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, et al. (March 2020). "A pneumonia outbreak associated with a new coronavirus of probable bat origin". Nature. 579 (7798): 270–273. doi:10.1038/s41586-020-2012-7. PMID 32015507.
- ^ a b Andersen KG, Rambaut A, Lipkin WI, Holmes EC, Garry RF (April 2020). "The proximal origin of SARS-CoV-2". Nature Medicine. 26 (4): 450–452. doi:10.1038/s41591-020-0820-9. PMID 32284615.
Higher taxonomy: Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Nidovirales > Cornidovirineae > Coronaviridae | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Translation from Chinese articles
| This article, RaTG13, has recently been created via the Articles for creation process. Please check to see if the reviewer has accidentally left this template after accepting the draft and take appropriate action as necessary.
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