The Group B of the 1999 Copa América was one of the three groups of competing nations in the 1999 Copa América. It comprised Brazil, Chile, Venezuela, and Mexico. Group play began on June 30 and ended on July 6.
Brazil won the group and faced Argentina, the runner-up of Group C, in the quarterfinals. Mexico finished second and faced Peru, the runner-up of Group A, in the quarterfinals. Chile finished third and faced Colombia, the winner of Group C, in the quarterfinals. Venezuela finished fourth in the group and was eliminated from the tournament.