|PDB structures||RCSB PDB PDBe PDBsum|
|Gene Ontology||AmiGO / QuickGO|
- 2,5-dioxopentanoate + NADP+ + H2O 2-oxoglutarate + NADPH + 2 H+
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2,5-dioxopentanoate:NADP+ 5-oxidoreductase. Other names in common use include 2-oxoglutarate semialdehyde dehydrogenase, and alpha-ketoglutaric semialdehyde dehydrogenase. This enzyme participates in ascorbate and aldarate metabolism.
- Adams E, Rosso G (April 1967). "Alpha-ketoglutaric semialdehyde dehydrogenase of Pseudomonas. Properties of the purified enzyme induced by hydroxyproline and of the glucarate-induced and constitutive enzymes". The Journal of Biological Chemistry. 242 (8): 1802–14. PMID 6024771.