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2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase

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2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase
Identifiers
EC no.1.3.1.40
CAS no.104645-83-2
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In enzymology, a 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase (EC 1.3.1.40) is an enzyme that catalyzes the chemical reaction

2,6-dioxo-6-phenylhexanoate + NADP+ 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + NADPH + H+

Thus, the two substrates of this enzyme are 2,6-dioxo-6-phenylhexanoate and NADP+, whereas its 3 products are 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2,6-dioxo-6-phenylhexanoate:NADP+ Delta2-oxidoreductase. Other names in common use include 2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide, and adenine dinucleotide phosphate) reductase.

References

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  • Omori T, Ishigooka H, Minoda Y (1986). "Purification and some properties of 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid(HOPDA) reducing enzyme from Pseudomonas cruciviae S93B1 involved in the degradation of biphenyl". Agric. Biol. Chem. 50 (6): 1513–1518. doi:10.1271/bbb1961.50.1513.