3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase

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3-alpha,7-alpha,12-alpha-trihydroxycholestan-26-al 26-oxidoreductase
Identifiers
EC number 1.2.1.40
CAS number 62213-58-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 3alpha,7alpha,12alpha-trihydroxycholestan-26-al 26-oxidoreductase is an enzyme that catalyzes the chemical reaction:[1]

(25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + NAD+ + H2O \rightleftharpoons (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + NADH + 2 H+

The 3 substrates of this enzyme are (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al, NAD+, and H2O, whereas its 2 products are (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate, NADH, and H+. This enzyme participates in bile acid biosynthesis.

Nomenclature[edit]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+ 26-oxidoreductase. Other names in common use include:

  • cholestanetriol-26-al 26-dehydrogenase,
  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al, dehydrogenase,
  • trihydroxydeoxycoprostanal dehydrogenase,
  • THAL-NAD oxidoreductase,
  • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al:NAD+, and
  • 26-oxidoreductase.

References[edit]

  1. ^ Masui T, Herman R, Staple E (March 1966). "The oxidation of 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha, 26-tetraol to 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol-26-oic acid via 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol-26-al by rat liver". Biochim. Biophys. Acta 117 (1): 266–8. doi:10.1016/0304-4165(66)90177-2. PMID 5914340.