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4-phosphopantoate—beta-alanine ligase

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4-Phosphopantoate—β-alanine ligase
Identifiers
EC no.6.3.2.36
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4-Phosphopantoate—β-alanine ligase (EC 6.3.2.36, phosphopantothenate synthetase, TK1686 protein) is an enzyme with systematic name (R)-4-phosphopantoate:beta-alanine ligase (AMP-forming).[1] This enzyme catalyses the following chemical reaction

ATP + (R)-4-phosphopantoate + β-alanine AMP + diphosphate + (R)-4'-phosphopantothenate

The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine.

References

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  1. ^ Yokooji Y, Tomita H, Atomi H, Imanaka T (October 2009). "Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the Archaea". The Journal of Biological Chemistry. 284 (41): 28137–45. doi:10.1074/jbc.m109.009696. PMC 2788864. PMID 19666462.
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