4-phosphopantoate—beta-alanine ligase
| 4-phosphopantoate—beta-alanine ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 6.3.2.36 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
4-phosphopantoate—beta-alanine ligase (EC 6.3.2.36, phosphopantothenate synthetase, TK1686 protein) is an enzyme with systematic name (R)-4-phosphopantoate:beta-alanine ligase (AMP-forming).[1] This enzyme catalyses the following chemical reaction
- ATP + (R)-4-phosphopantoate + beta-alanine AMP + diphosphate + (R)-4'-phosphopantothenate
The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine.
References
- ^ Yokooji, Y.; Tomita, H.; Atomi, H.; Imanaka, T. (2009). "Pantoate kinase and phosphopantothenate synthetase, two novel enzymes necessary for CoA biosynthesis in the Archaea". J. Biol. Chem. 284: 28137–28145. doi:10.1074/jbc.m109.009696. PMC 2788864. PMID 19666462.
{{cite journal}}: CS1 maint: unflagged free DOI (link)
External links
- 4-phosphopantoate—beta-alanine+ligase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)