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Histone H1.4 is a protein that in humans is encoded by the HIST1H1Egene.[5][6][7]
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.[7]
HIST1H1E syndrome
HIST1H1E syndrome is a rare autosomal dominant disorder caused by a heterozygous pathogenic variant in the HIST1H1E gene, which is characterized by a set of recognizable clinical features such as hypotonia, intellectual disability, behavioral issues, skeletal, testes (undescended) and thyroid, heart anomalies, and ectodermal issues.</ref>[8]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D (Nov 1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics. 10 (4): 940–8. doi:10.1016/0888-7543(91)90183-F. PMID1916825.
^Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID12408966.
Strom R, Santoro R, D'Erme M, et al. (1995). "Specific variants of H1 histone regulate CpG methylation in eukaryotic DNA". Gene. 157 (1–2): 253–6. doi:10.1016/0378-1119(95)91236-S. PMID7607502.
Albig W, Drabent B, Kunz J, et al. (1993). "All known human H1 histone genes except the H1(0) gene are clustered on chromosome 6". Genomics. 16 (3): 649–54. doi:10.1006/geno.1993.1243. PMID8325638.
Albig W, Kioschis P, Poustka A, et al. (1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID9119399.
Morrison H, Jeppesen P (2003). "Allele-specific underacetylation of histone H4 downstream from promoters is associated with X-inactivation in human cells". Chromosome Res. 10 (7): 579–95. doi:10.1023/A:1020966719605. PMID12498347. S2CID21076644.
Garcia BA, Busby SA, Barber CM, et al. (2005). "Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry". J. Proteome Res. 3 (6): 1219–27. doi:10.1021/pr0498887. PMID15595731.