Monocarboxylate transporter 6

SLC16A5
Identifiers
Aliases	SLC16A5, MCT5, MCT6, solute carrier family 16 member 5, Monocarboxylate transporter 6
External IDs	OMIM: 603879; MGI: 2443515; HomoloGene: 20985; GeneCards: SLC16A5; OMA:SLC16A5 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	75,106,162 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	115,365,224 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; mucosa of transverse colon; ; right uterine tube; ; pancreatic ductal cell; ; upper lobe of left lung; ; oocyte; ; duodenum; ; right lung; ; epithelium of nasopharynx; ; monocyte;
	Top expressed in
	thymus; ; jejunum; ; right kidney; ; duodenum; ; epithelium of stomach; ; colon; ; left colon; ; embryo; ; human kidney; ; ileum;
	More reference expression data
	n/a
Gene ontology
Molecular function	symporter activity; monocarboxylic acid transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	monocarboxylic acid transport; transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	9121
	217316
	ENSG00000170190
	ENSMUSG00000045775
	O15375
	G5E8K6
	NM_001271765; NM_004695; NM_001369668
	NM_001080934; NM_001359606; NM_001359608; NM_001359609
	NP_001258694; NP_004686; NP_001356597
	NP_001074403; NP_001346535; NP_001346537; NP_001346538
	Wikidata
View/Edit Human	View/Edit Mouse

Monocarboxylate transporter 6 (MCT6) is a protein in humans that is encoded by the SLC16A5 gene.^[5]

This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].

References

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