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Cardiotoxin III

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Cytotoxin 3
Identifiers
OrganismNaja atra
Symbol?
PDB1H0J
UniProtP60301
Search for
StructuresSwiss-model
DomainsInterPro

Cardiotoxin III (CTX III, also known as cytotoxin 3) is a sixty amino-acid polypeptide toxin from the Taiwan Cobra Naja atra. It is an example of a group of snake cardio/cytotoxins (InterPro: IPR003572), which are made up of shorter snake venom three-finger toxins.[1]

Recent evidence has shown that CTX III may induce apoptosis in K562 cells via the release of cytochrome c.[2]

References

  1. ^ "Superfamily » 2.2.39. Snake toxin-like (2 families) - Orientations of Proteins in Membranes (OPM) database". Retrieved 2008-12-13.
  2. ^ Yang SH, Chien CM, Lu MC, Lu YJ, Wu ZZ, Lin SR (July 2005). "Cardiotoxin III induces apoptosis in K562 cells through a mitochondrial-mediated pathway". Clin. Exp. Pharmacol. Physiol. 32 (7): 515–20. doi:10.1111/j.1440-1681.2005.04223.x. PMID 16026508.


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