Nucleoporin 43

NUP43
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4I79, 5A9Q
Identifiers
Aliases	NUP43, bA350J20.1, p42, nucleoporin 43kDa, nucleoporin 43
External IDs	OMIM: 608141; MGI: 1917162; HomoloGene: 11639; GeneCards: NUP43; OMA:NUP43 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q25.1 Start 149,724,315 bp End 149,749,665 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 A1 Start 7,543,267 bp End 7,554,645 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte seminal vesicula oral cavity pylorus hair follicle parietal pleura visceral pleura renal medulla germinal epithelium Top expressed in epiblast primary oocyte tail of embryo embryo genital tubercle secondary oocyte embryo morula blastocyst zygote More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytosol nuclear envelope nuclear pore chromosome chromosome, centromeric region nucleus kinetochore nuclear pore outer ring host cell Biological process mRNA transport chromosome segregation cell division protein transport cell cycle viral process mRNA export from nucleus regulation of glycolytic process tRNA export from nucleus protein sumoylation viral transcription regulation of gene silencing by miRNA intracellular transport of virus regulation of cellular response to heat Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 348995 69912 Ensembl ENSG00000120253 ENSMUSG00000040034 UniProt Q8NFH3 P59235 RefSeq (mRNA) NM_024647 NM_198887 NM_145706 RefSeq (protein) NP_942590 NP_663752 Location (UCSC) Chr 6: 149.72 – 149.75 Mb Chr 10: 7.54 – 7.55 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Nucleoporin 43 (Nup43) is a protein that in humans is encoded by the NUP43 gene.

Bidirectional transport of macromolecules between the cytoplasm and nucleus occurs through nuclear pore complexes (NPCs) embedded in the nuclear envelope. NPCs are composed of subcomplexes, and NUP43 is part of one such subcomplex, Nup107-160 (Loiodice et al., 2004).[supplied by OMIM]

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Loïodice I, Alves A, Rabut G, et al. (2005). "The entire Nup107-160 complex, including three new members, is targeted as one entity to kinetochores in mitosis". Mol. Biol. Cell. 15 (7): 3333–44. doi:10.1091/mbc.E03-12-0878. PMC 452587. PMID 15146057.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

External links

• Overview of all the structural information available in the PDB for UniProt: Q8NFH3 (Human Nucleoporin Nup43) at the PDBe-KB.