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TRNA-dihydrouridine16/17 synthase (NAD(P)+)

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TRNA-dihydrouridine16/17 synthase (NAD(P)+)
Identifiers
EC no.1.3.1.88
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
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MetaCycmetabolic pathway
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NCBIproteins

TRNA-dihydrouridine16/17 synthase (NAD(P)+) (EC 1.3.1.88, Dus1p, tRNA-dihydrouridine synthase 1) is an enzyme with systematic name tRNA-5,6-dihydrouracil16/17:NAD(P)+ oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

(1) 5,6-dihydrouracil16 in tRNA + NAD(P)+ uracil16 in tRNA + NAD(P)H + H+
(2) 5,6-dihydrouracil17 in tRNA + NAD(P)+ uracil17 in tRNA + NAD(P)H + H+

This enzyme specifically modifies uracil16 and uracil17 in tRNA.

References

  1. ^ Xing F, Hiley SL, Hughes TR, Phizicky EM (April 2004). "The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs". The Journal of Biological Chemistry. 279 (17): 17850–60. doi:10.1074/jbc.M401221200. PMID 14970222.
  2. ^ Xing F, Martzen MR, Phizicky EM (March 2002). "A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA". RNA. 8 (3): 370–81. doi:10.1017/S1355838202029825. PMC 1370258. PMID 12003496.