GTF3C5

GTF3C5
Identifiers
Aliases	GTF3C5, TFIIIC63, TFIIICepsilon, TFiiiC2-63, general transcription factor IIIC subunit 5
External IDs	OMIM: 604890; MGI: 1917489; HomoloGene: 40806; GeneCards: GTF3C5; OMA:GTF3C5 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q34.13 Start 133,030,675 bp End 133,058,503 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 A3 Start 28,456,323 bp End 28,473,763 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube anterior pituitary canal of the cervix tibial nerve skin of abdomen left uterine tube right lobe of thyroid gland left lobe of thyroid gland right adrenal gland ganglionic eminence Top expressed in yolk sac neural tube internal carotid artery external carotid artery spermatocyte morula ganglionic eminence lip dermis lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding RNA polymerase III type 1 promoter sequence-specific DNA binding RNA polymerase III type 2 promoter sequence-specific DNA binding RNA polymerase III general transcription initiation factor activity Cellular component transcription factor TFIIIC complex nucleus nucleoplasm Biological process skeletal muscle cell differentiation tRNA transcription by RNA polymerase III 5S class rRNA transcription by RNA polymerase III transcription, DNA-templated transcription by RNA polymerase III RNA polymerase III preinitiation complex assembly transcription initiation from RNA polymerase III promoter Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9328 70239 Ensembl ENSG00000148308 ENSMUSG00000026816 UniProt Q9Y5Q8 Q8R2T8 RefSeq (mRNA) NM_001122823 NM_001286709 NM_012087 NM_001290484 NM_148928 RefSeq (protein) NP_001116295 NP_001273638 NP_036219 NP_001277413 NP_683730 Location (UCSC) Chr 9: 133.03 – 133.06 Mb Chr 2: 28.46 – 28.47 Mb PubMed search
Wikidata
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General transcription factor 3C polypeptide 5 is a protein that in humans is encoded by the GTF3C5 gene.

Model organisms

Gtf3c5 knockout mouse phenotype

Characteristic	Phenotype
Homozygote viability	Abnormal
Recessive lethal study	Abnormal
Fertility	Normal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology	Normal
Peripheral blood lymphocytes	Normal
Micronucleus test	Normal
Heart weight	Normal
Eye Histopathology	Normal
Salmonella infection	Normal
Citrobacter infection	Normal
All tests and analysis from

Model organisms have been used in the study of GTF3C5 function. A conditional knockout mouse line, called Gtf3c5^{tm2a(KOMP)Wtsi} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on mutant mice and two significant abnormalities were observed. No homozygous mutant embryos were identified during gestation, and therefore none survived until weaning. The remaining tests were carried out on heterozygous mutant adult mice; no additional significant abnormalities were observed in these animals.

Interactions

GTF3C5 has been shown to interact with GTF3C2 and GTF3C4.

Further reading

• Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
• Dumay-Odelot H, Marck C, Durrieu-Gaillard S, Lefebvre O, Jourdain S, Prochazkova M, Pflieger A, Teichmann M (2007). "Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC". J. Biol. Chem. 282 (23): 17179–89. doi:10.1074/jbc.M611542200. PMID 17409385.