BCL3

For BCl₃, see Boron trichloride.

BCL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1K1A, 1K1B
Identifiers
Aliases	BCL3, BCL4, D19S37, B-cell CLL/lymphoma 3, B cell CLL/lymphoma 3, transcription coactivator, BCL3 transcription coactivator
External IDs	OMIM: 109560; MGI: 88140; HomoloGene: 81738; GeneCards: BCL3; OMA:BCL3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.32 Start 44,747,705 bp End 44,760,044 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 A3|7 9.95 cM Start 19,542,387 bp End 19,556,695 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left uterine tube right lobe of liver upper lobe of left lung gastric mucosa mucosa of transverse colon spleen apex of heart olfactory zone of nasal mucosa left adrenal cortex right lung Top expressed in lumbar spinal ganglion granulocyte mesenteric lymph nodes intestinal villus jejunum left lobe of liver duodenum colon ileum ankle joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein-macromolecule adaptor activity DNA-binding transcription factor activity transcription factor binding protein binding Cellular component cytoplasm Bcl3-Bcl10 complex nucleoplasm perinuclear region of cytoplasm Bcl3/NF-kappaB2 complex nucleus cytosol plasma membrane midbody intracellular membrane-bounded organelle protein-containing complex Biological process regulation of apoptotic process intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator regulation of DNA binding regulation of transcription, DNA-templated T-helper 2 cell differentiation antimicrobial humoral response germinal center formation response to virus DNA damage response, signal transduction by p53 class mediator extracellular matrix organization positive regulation of interferon-gamma production negative regulation of apoptotic process spleen development marginal zone B cell differentiation positive regulation of translation transcription, DNA-templated cellular response to DNA damage stimulus positive regulation of transcription, DNA-templated humoral immune response mediated by circulating immunoglobulin follicular dendritic cell differentiation defense response to bacterium T-helper 1 type immune response negative regulation of transcription, DNA-templated I-kappaB kinase/NF-kappaB signaling response to UV-C maintenance of protein location in nucleus positive regulation of transcription by RNA polymerase II defense response to protozoan negative regulation of receptor signaling pathway via JAK-STAT regulation of NIK/NF-kappaB signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 602 12051 Ensembl ENSG00000069399 ENSMUSG00000053175 UniProt P20749 Q9Z2F6 RefSeq (mRNA) NM_005178 NM_033601 RefSeq (protein) NP_005169 NP_291079 Location (UCSC) Chr 19: 44.75 – 44.76 Mb Chr 7: 19.54 – 19.56 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3 gene.

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.

Like BCL2, BCL5, BCL6, BCL7A, BCL9, and BCL10, it has clinical significance in lymphoma.

Interactions

BCL3 has been shown to interact with:

• BARD1,
• C-Fos,
• C-jun,
• C22orf25,
• COPS5,
• EP300,
• HTATIP,
• NFKB1,
• NFKB2,
• PIR, and
• NR2B1.

Further reading

• Franzoso G, Bours V, Park S, Tomita-Yamaguchi M, Kelly K, Siebenlist U (September 1992). "The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibition". Nature. 359 (6393): 339–42. doi:10.1038/359339a0. PMID 1406939. S2CID 4322739.
• Bhatia K, Huppi K, McKeithan T, Siwarski D, Mushinski JF, Magrath I (September 1991). "Mouse bcl-3: cDNA structure, mapping and stage-dependent expression in B lymphocytes". Oncogene. 6 (9): 1569–73. PMID 1923524.
• Mills FC, Brooker JS, Camerini-Otero RD (1991). "Sequences of human immunoglobulin switch regions: implications for recombination and transcription". Nucleic Acids Res. 18 (24): 7305–16. doi:10.1093/nar/18.24.7305. PMC 332867. PMID 2124350.
• Crossen PE, Kennedy MA, Heaton DC, Morrison MJ (1993). "Cloning and sequencing of a t(14;19) breakpoint that involves the C mu switch region". Genes Chromosomes Cancer. 8 (1): 60–2. doi:10.1002/gcc.2870080110. PMID 7691160. S2CID 85217954.
• McKeithan TW, Ohno H, Dickstein J, Hume E (1995). "Genomic structure of the candidate proto-oncogene BCL3". Genomics. 24 (1): 120–6. doi:10.1006/geno.1994.1588. PMID 7896265.
• Zhang Q, Didonato JA, Karin M, McKeithan TW (1994). "BCL3 encodes a nuclear protein which can alter the subcellular location of NF-kappa B proteins". Mol. Cell. Biol. 14 (6): 3915–26. doi:10.1128/MCB.14.6.3915. PMC 358758. PMID 8196632.
• Fujita T, Nolan GP, Liou HC, Scott ML, Baltimore D (July 1993). "The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers". Genes Dev. 7 (7B): 1354–63. doi:10.1101/gad.7.7b.1354. PMID 8330739.
• Naumann M, Wulczyn FG, Scheidereit C (1993). "The NF-kappa B precursor p105 and the proto-oncogene product Bcl-3 are I kappa B molecules and control nuclear translocation of NF-kappa B". EMBO J. 12 (1): 213–22. doi:10.1002/j.1460-2075.1993.tb05647.x. PMC 413194. PMID 8428580.
• Bours V, Franzoso G, Azarenko V, Park S, Kanno T, Brown K, Siebenlist U (March 1993). "The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers". Cell. 72 (5): 729–39. doi:10.1016/0092-8674(93)90401-B. PMID 8453667.
• Nolan GP, Fujita T, Bhatia K, Huppi C, Liou HC, Scott ML, Baltimore D (June 1993). "The bcl-3 proto-oncogene encodes a nuclear I kappa B-like molecule that preferentially interacts with NF-kappa B p50 and p52 in a phosphorylation-dependent manner". Mol. Cell. Biol. 13 (6): 3557–66. doi:10.1128/MCB.13.6.3557. PMC 359825. PMID 8497270.
• Watanabe N, Iwamura T, Shinoda T, Fujita T (June 1997). "Regulation of NFKB1 proteins by the candidate oncoprotein BCL-3: generation of NF-kappaB homodimers from the cytoplasmic pool of p50-p105 and nuclear translocation". EMBO J. 16 (12): 3609–20. doi:10.1093/emboj/16.12.3609. PMC 1169985. PMID 9218802.
• Bundy DL, McKeithan TW (1998). "Diverse effects of BCL3 phosphorylation on its modulation of NF-kappaB p52 homodimer binding to DNA". J. Biol. Chem. 272 (52): 33132–9. doi:10.1074/jbc.272.52.33132. PMID 9407099.
• Weyrich AS, Dixon DA, Pabla R, Elstad MR, McIntyre TM, Prescott SM, Zimmerman GA (May 1998). "Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets". Proc. Natl. Acad. Sci. U.S.A. 95 (10): 5556–61. doi:10.1073/pnas.95.10.5556. PMC 20416. PMID 9576921.
• Na SY, Choi HS, Kim JW, Na DS, Lee JW (November 1998). "Bcl3, an IkappaB protein, as a novel transcription coactivator of the retinoid X receptor". J. Biol. Chem. 273 (47): 30933–8. doi:10.1074/jbc.273.47.30933. PMID 9812988.
• Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A (June 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene. 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. PMID 10362352.
• Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW (October 1999). "Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation". J. Biol. Chem. 274 (40): 28491–6. doi:10.1074/jbc.274.40.28491. PMID 10497212.
• Neumann M, Fries H, Scheicher C, Keikavoussi P, Kolb-Mäurer A, Bröcker E, Serfling E, Kämpgen E (January 2000). "Differential expression of Rel/NF-kappaB and octamer factors is a hallmark of the generation and maturation of dendritic cells". Blood. 95 (1): 277–85. doi:10.1182/blood.V95.1.277. PMID 10607713.
• Brasier AR, Lu M, Hai T, Lu Y, Boldogh I (August 2001). "NF-kappa B-inducible BCL-3 expression is an autoregulatory loop controlling nuclear p50/NF-kappa B1 residence". J. Biol. Chem. 276 (34): 32080–93. doi:10.1074/jbc.M102949200. PMID 11387332.

External links

• FactorBook BCL3
• Human BCL3 genome location and BCL3 gene details page in the UCSC Genome Browser.