ALDH1L1

ALDH1L1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BW0, 2CFI, 2CQ8
Identifiers
Aliases	ALDH1L1, 10-FTHFDH, 10-fTHF, FDH, FTHFD, aldehyde dehydrogenase 1 family member L1
External IDs	OMIM: 600249 MGI: 1340024 HomoloGene: 122031 GeneCards: ALDH1L1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	126,197,994 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	90,577,185 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; kidney; ; parotid gland; ; gastrocnemius muscle; ; optic nerve; ; gastric mucosa; ; caudate nucleus; ; amygdala; ; body of pancreas; ; putamen;
	Top expressed in
	left lobe of liver; ; kidney; ; proximal tubule; ; left colon; ; intestinal villus; ; jejunum; ; adrenal gland; ; white adipose tissue; ; optic nerve; ; subcutaneous adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	formyltetrahydrofolate dehydrogenase activity; oxidoreductase activity; hydroxymethyl-, formyl- and related transferase activity; catalytic activity; aldehyde dehydrogenase (NAD+) activity; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;
Cellular component	extracellular exosome; mitochondrion; cytoplasm; cytosol;
Biological process	metabolism; one-carbon metabolic process; biosynthesis; 10-formyltetrahydrofolate catabolic process; folic acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	10840
	107747
	ENSG00000144908
	ENSMUSG00000030088
	O75891
	Q8R0Y6
	NM_001270364; NM_001270365; NM_012190; NM_144776
	NM_027406; NM_001356412
	NP_001257293; NP_001257294; NP_036322
	NP_081682; NP_001343341
	Wikidata
View/Edit Human	View/Edit Mouse

10-formyltetrahydrofolate dehydrogenase is an enzyme that in humans is encoded by the ALDH1L1 gene.^[5]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000144908 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030088 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ALDH1L1 aldehyde dehydrogenase 1 family, member L1".

External links

Human ALDH1L1 genome location and ALDH1L1 gene details page in the UCSC Genome Browser.

v t e Aldehyde dehydrogenases (EC 1.2.1)
Family 1	Retinaldehyde — ALDH1A1 ALDH1A2 ALDH1A3 ALDH1B1 Formyltetrahydrofolate — ALDH1L1 ALDH1L2
Family 2 (mitochondrial)	ALDH2
Family 3	Dimeric NADP-preferring — (ALDH3A1) Fatty aldehyde — (ALDH3A2) ALDH3B1 ALDH3B2
Other	ALDH4A1 ALDH5A1 ALDH6A1 α-Aminoadipic semialdehyde — (ALDH7A1) ALDH8A1 ALDH9A1 ALDH16A1 ALDH18A1 Glyceraldehyde 3-phosphate — (GAPDH)

References

External links

Further reading