ANAPC4

ANAPC4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4UI9, 5BPW, 5A31, 5G05, 5G04
Identifiers
Aliases	ANAPC4, APC4, anaphase promoting complex subunit 4
External IDs	OMIM: 606947; MGI: 1098673; HomoloGene: 40873; GeneCards: ANAPC4; OMA:ANAPC4 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	25,418,498 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	53,025,139 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; endometrium; ; tendon of biceps brachii; ; germinal epithelium; ; bronchial epithelial cell; ; parietal pleura; ; visceral pleura; ; Brodmann area 23; ; thymus; ; tibia;
	Top expressed in
	primary oocyte; ; neural layer of retina; ; superior cervical ganglion; ; ventricular zone; ; pituitary gland; ; vas deferens; ; ganglionic eminence; ; limb bud; ; fossa; ; condyle;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin-protein transferase activity; protein phosphatase binding; protein binding; ubiquitin protein ligase activity;
Cellular component	anaphase-promoting complex; cytosol; nucleus; nucleoplasm; nuclear periphery;
Biological process	anaphase-promoting complex-dependent catabolic process; regulation of mitotic metaphase/anaphase transition; cell division; protein K11-linked ubiquitination; cell cycle; protein ubiquitination; positive regulation of mitotic metaphase/anaphase transition; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	29945
	52206
	ENSG00000053900
	ENSMUSG00000029176
	Q9UJX5
	Q91W96
	NM_001286756; NM_013367
	NM_024213
	NP_001273685; NP_037499
	NP_077175
	Wikidata
View/Edit Human	View/Edit Mouse

Anaphase-promoting complex subunit 4 is an enzyme that in humans is encoded by the ANAPC4 gene.^[5]^[6]

Template:PBB Summary

Interactions

ANAPC4 has been shown to interact with ANAPC1,^[7]^[8] ANAPC5,^[7] CDC27^[7]^[9] and ANAPC7.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000053900 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029176 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tekolf WA, Biddison WE, Aster RD, Shaw S (October 1982). "Two subgroups of HLA Bw44 defined by cell-mediated lympholysis that differ in Bw44 expression on platelets and in patterns of genetic linkage disequilibrium". J Immunol. 129 (4): 1474–8. PMID 6180011.
^ "Entrez Gene: ANAPC4 anaphase promoting complex subunit 4".
^ ^a ^b ^c ^d Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17). England: 1459–68. doi:10.1016/S0960-9822(03)00581-5. ISSN 0960-9822. PMID 12956947. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)
^ Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". J. Cell Biol. 151 (4). UNITED STATES: 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443. PMID 11076961. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Gmachl, M; Gieffers C; Podtelejnikov A V; Mann M; Peters J M (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16). UNITED STATES: 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. ISSN 0027-8424. PMC 16806. PMID 10922056. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

External links

Human ANAPC4 genome location and ANAPC4 gene details page in the UCSC Genome Browser.

Interactions

References

External links

Further reading