According to Cheyne and Black, this term is used to label Haman, figuratively, as a "descendant" of Agag, the enemy of Israel and king of the Amalekites. "Haman, as an Amalekite, is opposed to Mordecai, the descendant of Kish (Esth[er] 2:5) ... The meaning is that there is an internecine struggle between the Jews and their enemies, like that between Saul and Agag of old." With this understanding, the Greek translator rendered the term "Macedonian."
A well known Midrashic explanation of the term relates it to King Agag of the Amalekites whereby it is viewed as meaning either a literal descendant of Agag or an antisemite, the Amalekites having come to be symbolic of the antithesis of Judaism.
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