The community takes its name from Antioch, Turkey, an ancient city in Anatolia. As recently as the 1960s Antioch was a small community catering to the needs of area farmers with amenities such as a feed mill. Adjacent to Bakertown (a similar small community) it was located on the banks of Mill Creek, a minor tributary of the Cumberland River that rises near Nolensville, several miles to the southeast. This area has become less important over time as zoning restrictions forbidding further development on a floodplain have limited the construction of more businesses in this area, which had started to become congested.[original research?]
In the 1970s, Antioch experienced explosive growth, largely due to the expansion of the Nashville sewer system to the area and the availability of large amounts of former farmland, which made possible the construction of many low-rise apartment complexes, and several mobile home communities. The area continues to experience some of the highest growth rates in Nashville-Davidson County. Today the area has become notable for being Nashville's largest middle class African-American area.
On August 5, 2015 police shot Vincente David Montano at Carmike Hickory 8 theatre in Antioch during an attempted pepper spray attack that left three people injured. Montano had a history of mental illness and attempted to fire at officers with an airsoft pistol. 
The most important business concentration in Antioch is Global Mall at the Crossings, formerly Hickory Hollow Mall, which opened in 1978. At Hickory Hollow Mall, it was a regional shopping mall with a gross leasing area of 1,107,476 sq ft (102,887.9 m2), more than 140 stores, and 5,795 parking spaces. Anchor stores included Sears, and Macy's. As of late 2008, the mall had seen an increase in store closures, including larger stores such as Dillard's and Linens 'n Things.[not in citation given] A Walmart Supercenter and many new strip malls have also opened in the area. Large-scale home builders such as Beazer and Centex Homes have constructed many new subdivisions. As of February 2013, Target left the Antioch area.
Starwood Amphitheatre, Nashville's former primary outdoor music venue, was located in Antioch. The amphitheatre was closed prior to the 2007 season, and has since been demolished.
- "Antioch History". Antioch High School Alumni Association., Retrieved 2013-05-29.
- Nashville & Davidson County Metropolitan Planning Commission, Antioch/Priest Lake Community Plan: 2003 Update, Main Plan Document, page 5. (Page 137 of PDF retrieved on January 24, 2011.)
- "Fact Sheet - Hickory Hollow Mall". CBL and Associations Properties. Archived from the original on March 17, 2012.
- National Association of Free Will Baptists