Beijing Genomics Institute

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BGI
Private, Public
IndustryGenome sequencing
Biotechnology
FoundedSeptember 9, 1999 (Beijing)
FounderWang Jian
Yu Jun
Yang Huanming
Liu Siqi
HeadquartersShenzhen, Guangdong, China
Number of locations
Area served
Worldwide
Key people
Wang Jian (President, Chairman)
ProductsBGISEQ, MGISEQ
RevenueIncrease $251 million (2016)[1]
Increase $51.7 million (2016)[1]
OwnerWang Jian
Number of employees
~ 5,000 (worldwide)
DivisionsBGI China (Mainland)
BGI Asia Pacific
BGI Americas
BGI Europe (Europe and Africa)
Subsidiaries
Websitewww.bgi.com/global/
www.genomics.cn

BGI (Chinese: 华大基因; pinyin: Huádà Jīyīn), known as the Beijing Genomics Institute prior to 2008 and as the BGI Group, is a genome sequencing center, headquartered in Shenzhen, Guangdong, China.[2] It was formed in 1999 to participate in the Human Genome Project, and is the world's largest genetics research center.[3] It is considered to be world's leader in gene-sequencing services, sequencing genome also of other animals, plants and microorganisms.[4] In 2013 it bought Complete Genomics in Mountain View, California for US$118 million, and develops, manufactures and markets genome sequencing technology.[4]

History[edit]

Wang Jian, Yu Jun, Yang Huanming and Liu Siqi created BGI in November 1999,[4] in Beijing, China as a non-governmental independent research institute in order to participate in the Human Genome Project as China's representative.[5][6] After the project was completed, funding dried up. So BGI moved to Hangzhou in exchange for funding from the Hangzhou Municipal Government. In 2002, BGI sequenced the rice genome which was a cover story in the journal Science. In 2003 BGI decoded the SARS virus genome and created a kit for detection of the virus. In 2003, BGI Hangzhou and the Zhejiang University founded a new research institute, the James D. Watson Institute of Genome Sciences, Zhejiang University. The Watson Institute was intended to become a major center for research and education in East Asia modeled after the Cold Spring Harbor Laboratory in the US.

In 2007 BGI's headquarters relocated to Shenzhen as "the first citizen-managed, non-profit research institution in China". Yu Jun left BGI at this time purportedly selling his stake to the other 3 founders for a nominal sum.[4] In 2008, BGI-Shenzhen was officially recognized as a non-profit organization by Shenzhen government.[7] In 2008, BGI published the first human genome of an Asian individual.[5][8]

In 2010 BGI Shenzhen was certified as meeting the requirements of ISO9001:2008 standard for the design and provision of high-throughput sequencing services,[9] The same year BGI bought 128 Illumina's HiSeq 2000 gene-sequencing machines,[3][5] which was backed by US$1.5 billion in "collaborative funds" over the next 10 years from the China Development Bank.[4][10][11] By the end of the year, they reportedly had a budget of $30 million.[12] In 2010, BGI Americas was established with its main office in Cambridge, Massachusetts, USA, and BGI Europe was established in Copenhagen, Denmark.[13][14] By 2018, they were expanded with offices and laboratories in Seattle and San Jose in USA,[3] and London in the UK, as well were founded BGI Asia Pacific with offices in Hong Kong, Kobe (Japan), Bangkok (Thailand), Laos, Singapore, Brisbane (Australia) and many others.[15][16]

In 2011 BGI reported it employed 4,000 scientists and technicians,[2] and had a $192 million in revenue.[4] BGI did the genome sequencing for the deadly 2011 Germany E. coli O104:H4 outbreak in three days under an open license.[17] Since 2012 it started to commercialize its services, having investments from China Life Insurance Company, Citic's Goldstone Investment, Jack Ma's Yunfeng Capital, and SoftBank China Capital.[18] In 2013 BGI reported it had relationships with 17 out of the top 20 global pharmaceutical companies,[4][19] and advertised that it provided commercial science, health, agricultural, and informatics services to global pharmaceutical companies.[20] That year it bought Complete Genomics of Mountain View, California, a major supplier of DNA sequencing technology, for US$118 million.[4][17] In the same year, the BGI was roughly valued at $820 million.[4]

In 2015, they signed a collaboration with the Zhongshan Hospital' Center for Clinical Precision Medicine in Shanghai, opened in May 2015 with a budget of ¥100 million. They are reportedly being involved as a sequencing institution in China's US$9.2-billion research project for medical care which will last for 15 years.[3][21] In May 2017, was announced formation of West Coast Innovation Center, co-located in Seattle and San Jose, on the first location planned to work on precision medicine and feature collaborations with University of Washington, the Allen Institute for Brain Science, the Bill & Melinda Gates Foundation, and Washington State University, while on the second's already existing laboratory with 100 employees to develop the next-generation sequencing technologies.[3] In May 2018, was reached an agreement with Mount Sinai Hospital (Toronto), Canada, for first installation of BGISEQ platforms in North America.[22]

The BGI Group subsidiary, BGI Genomics, had made initial public offering in July 2017 at Shenzhen Stock Exchange, raising ¥547 million ($80.7 million), with company's first-day valuation set at over $1.15 billion.[1][23] In 2018, BGI was reportedly 85.3% owned by Wang Jian, and the group owns 42.4% of its main unit BGI Genomics. The reported market value for BGI Genomics in July 2018 was around $5 billion, as is of another subsidiary, MGI Tech, specialized in developing and manufacturing technology, which IPO of a stake of about 20% for $1 billion is scheduled for 2019 in Hong Kong.[18]

Key achievements[edit]

  • First to de novo sequence and assemble mammalian[24] and human genomes with short-read sequencing (so-called "next generation sequencing")[25]
  • Sequenced the first ancient human’s genome[26]
  • Sequenced the first diploid genome of an Asian individual,[27] as part of the Yan Huang project
  • Initiated building a sequence map of the human pan-genome, estimated to contain 19-40 million bases not in the human reference genome[28][29]
  • BGI's first project was contributing 1% of the Human Genome Project’s reference genome and was the only institute in the developing world to contribute[30]
  • Contributed 10% of sequence information for the International HapMap Project[30]
  • Produced proof-of-principle study for sequencing the microbiome of the human digestive system, an estimated 150 times larger than the human genome[31][32]
  • Key sequencing center in the 1000 Genomes Project[30]
  • First Chinese institution to sequence the Severe acute respiratory syndrome (SARS) virus, just hours after the first sequencing of the virus by Canadians[33]
  • Key player in the analysis of the 2011 E. coli O104:H4 outbreak[34]
  • Sequenced 40 domesticated and wild silkworms, identifying 354 genes likely important in domestication.[35]
  • Sequenced the first giant panda genome,[24] equal in size to the human genome, in less than 8 months.[36] Sequencing revealed that the giant panda, Ailuropoda melanoleuca, has a frameshift mutation in a gene involved in sensing savory flavors, T1R1. The mutation might be the genetic reason why the panda prefers bamboo over meat. However, the panda also lacks genes expected for bamboo digestion, so its microbiome might play a key role in metabolizing its main source of food.[24]
  • Key player in the Sino-British Chicken Genome Project[30]
  • As of 2010, plant genomes sequenced include rice, cucumber, soybean, and Sorghum. Animal genomes sequenced include silkworm, honey bee, water flea, lizard, and giant panda. An additional 40 animal and plant species and over 1000 bacteria had also been sequenced.[6][35][37]
  • Nature in 2010 ranked BGI Shenzhen as the 4th among the top 10 institutions in China with all the others being universities and the Chinese Academy of Sciences. The ranking was based on articles in Nature research journals.[38] By 2016, it topped the corporate institutions list in China as well was 13th corporate institution on global scale.[38][39][40] In 2017, among the most productive corporate–academic collaborations between 2012 and 2016, the BGI and University of Copenhagen partnership was ranked as 4th.[41]
  • Between 2001 and 2013, BGI featured in around 250 papers published in first-class academic journals.[42]
  • In 2014, BGI was reported to be producing 500 cloned pigs a year to test new medicines,[43] and roughly 25% of world's genomic data.[3]
  • In January 2018, BGI Genomics CEO, Yin Ye, stated they sequenced over 10,000 WGS samples, with additional 20,000 being sequenced by their BGISEQ-500 platform, about 70% of animals and plants until now were sequenced by the company and their partners, as well worked on "over 10 million clinical samples, including running 2.8 million noninvasive prenatal tests, 2.6 million human papillomavirus tests, 1.53 million hearing impairment tests, just over half a million newborn screening tests, and around 25,000 rare disease tests".[44]

Current research projects[edit]

Human genetics[edit]

Human Genome Project[edit]

An international project launched in 1990 and declared complete in 2003. They joined in 1999 and provided 1% of the workload.[42]

International HapMap Project[edit]

An international project launched in 2002 and declared complete in 2009. They provided 10% of the workload.[42]

Yan Huang Project[edit]

Started in 2007 and named after two Emperors believed to have founded China’s dominant ethnic group,[45] BGI planned in this project, to sequence at least 100 Chinese individuals to produce a high-resolution map of Chinese genetic polymorphisms.[46][47] The first genome data was published in October 2007.[48] An anonymous Chinese billionaire donated $10 million RMB (about US$1.4 million) to the project and his genome was sequenced at the beginning of the project.[46][47]

1000 Genomes Project[edit]

An international project launched in 2008 and declared complete in 2015.[42]

International Cancer Genome Project[edit]

An international project launched in 2008.[42]

1000 Rare Disease Project[edit]

An international projected jointly initiated with Children's Hospital of Philadelphia in 2011.[42] With it were discovered genes and mutations associated with rare diseases, which was reported in more than 20 scientific publications. They also "co-developed a clinical whole exome diagnostic test offered through CHOP pathology since 2012". They again collaborated in 2017 when CHOP's Children’s Brain Tumor Tissue Consortium was joined by BGI's China National GeneBank.[49]

Intelligence Project[edit]

A Chinese project focused on the research of the genetic basis of intelligence launched in August 2012. American physicist Steve Hsu joined as a scientific adviser and one of the project's leaders.[50] It was done on 2,200 samples mostly from the United States,[42] out of which 1,600 were of individuals who participated in the Study of Mathematically Precocious Youth and reportedly have IQs over 160, collected by American psychologist and geneticist Robert Plomin.[50][51]

Animals and plants[edit]

1000 Plant Genome Project[edit]

An international project launched in 2008 and declared complete in 2015. In 2010, BGI has announced it will contribute US$100 million to large-scale sequencing projects of plants and animals.[11][52]

Three Extreme-Environment Animal Genomes Project[edit]

In 2009 BGI-Shenzhen announced the launch of three genome projects that focus on animals living in extreme environments. The three selected genomes are those of two polar animals: the polar bear and emperor penguin, and one altiplano animal: the Tibetan antelope.[53]

International Big Cats Genome Project[edit]

In 2010, BGI, Beijing University, Heilongjiang Manchurian tiger forestry zoo, Kunming Institute of Zoology, San Diego Zoo Institute for Conservation Research in California, and others announced they would sequence the Amur tiger, South China tiger, Bengal tiger, Asiatic lion, African lion, clouded leopard, snow leopard, and other felines. BGI would also sequence the genomes and epigenoms of a liger and tigon. Since the two reciprocal hybrids have different phenotypes, despite being genetically identical, it was expected that the epigenome might reveal the basis of such differences.[54] The project aim was to significantly advance conservation research and was auspiciously announced for the Chinese year of the Tiger.[55] Results were reported in 2013 for the genomes of the Anur tiger, the white Bengal tiger, African lion, white African lion and snow leopard.[56]

Symbiont Genome Project[edit]

A jointly funded project announced on 19 March 2010, BGI will collaborate with Sidney K. Pierce of University of South Florida and Charles Delwiche of the University of Maryland at College Park to sequence the genomes of the sea slug, Elysia chlorotica, and its algal food Vaucheria litorea. The sea slug uses genes from the algae to synthesize chlorophyll, the first interspecies of gene transfer discovered. Sequencing their genomes could elucidate the mechanism of that transfer.[57]

Earth BioGenome Project[edit]

An international project initiated with the Smithsonian Institution and other partners in 2018, to sequence DNA of the 1.5 million known eukaryotic species on the planet.[49]

Microorganisms[edit]

Ten Thousand Microbial Genomes Project[edit]

The project was started on 1 August 2009, with the mission to sequence 10,000 microbes within 3 years. It includes sequencing industrial, agricultural, medical microorganism and many others. It is done in collaboration with many institutes, universities and enterprises, including Biotechnology Research Institute of the Chinese Academy of Agricultural Sciences and the Tianjin Institute of Industrial Biotechnology of Chinese Academy of Sciences.[58]

Bioinformatics technology[edit]

In 2010, the institute 500-node supercomputer processed 10 terabytes of raw sequencing data every 24 hours from its current 30 or so Genome Analyzers from Illumina. The annual budget for the computer center was US$9 million.[12] In the same year, BGI's computational biologists developed the first successful algorithm, based on graph theory, for aligning billions of 25 to 75-base pair strings produced by next-generation sequencers, specifically Illumina’s Genome Analyzer, during de novo sequencing. The algorithm, called SOAPdenovo, can assemble a genome in two days and has been used to sequence an array of plant and animal genomes.[29]

SOAPdenovo is part of "Short Oligonucleotide Analysis Package" (SOAP), a suite of tools developed by BGI for de novo assembly of human-sized genomes, alignment, SNP detection, resequencing, indel finding, and structural variation analysis. Built for the Illumina sequencers' short reads, SOAPdenovo has been used to assemble multiple human genomes[25][26][27] (identifying an eight kilobase insertion not detected by mapping to the human reference genome[59]) and animals, like the giant panda.[24]

Until 2015, BGI had released BGISEQ-100, based on Thermo Fisher Scientific's Ion Torrent device, and BGISEQ-1000, based on similar technology by Complete Genomics, for both of which received an approval from the CFDA for a NIFTY noninvasive prenatal test.[60][61] In October 2015, BGI launched BGISEQ-500,[62] a larger desktop sequencing system, which received an approved registration as a medical device a year later by the CFDA. It reportedly received more than 500 orders for the system and run over 112,000 tests until late 2016.[61] The China National GeneBank, opened by BGI and Chinese Government in September 2016,[63] has 150 instruments of the system.[61] The BGISEQ-500 was developed as a sequencing platform capable of competing with Illumina's platforms with its quality and reduced price.[60] In November 2016, BGI launched BGISEQ-50, a miniature version of desktop sequencer.[64] In 2017, BGI began offering WGS for $600.[3] In October 2017, MGI Tech, a subsidiary of BGI, launched two new sequencers MGISEQ-2000 and MGISEQ-200,[65] while a year later MGISEQ-T7.[66]

See also[edit]

References[edit]

  1. ^ a b c "BGI Genomics Raises $81M in IPO". Genetic Engineering & Biotechnology News. 17 July 2017. Retrieved 2 December 2018.
  2. ^ a b Lone Frank, High-Quality DNA, Apr 24, 2011, The Daily Beast
  3. ^ a b c d e f g Megan Molteni (18 May 2017). "A Chinese Genome Giant Sets Its Sights on the Ultimate Sequencer". Wired. Retrieved 2 December 2018.
  4. ^ a b c d e f g h i Shu-Ching Jean Chen (2 September 2013). "Genomic Dreams Coming True in China". Forbes Asia. Retrieved 27 October 2014.
  5. ^ a b c Kevin Davies, (27 September 2011) The Bedrock of BGI: Huanming Yang Bio-IT World, Retrieved 14 January 2014
  6. ^ a b The dragon's DNA, Jun 17th 2010, The Economist
  7. ^ About BGI, BGI
  8. ^ Ye, Jia (2008) An Interview with a Leader in Genomics — Beijing Genomics Institute Asia Biotech, Retrieved 14b January 2013
  9. ^ "Next Generation of High-Throughput Sequencing Service of BGI Received the ISO9001 Certification". 23 March 2010. Retrieved 14 January 2014.
  10. ^ "BGI to Receive $1.5B in 'Collaborative Funds' Over 10 Years from China Development Bank | In Sequence | Sequencing | GenomeWeb". Retrieved 29 March 2010.
  11. ^ a b Fox, J.; Kling, J. (2010). "Chinese institute makes bold sequencing play". Nature Biotechnology. 28 (3): 189–191. doi:10.1038/nbt0310-189c. PMID 20212469.
  12. ^ a b Petsko, G. A. (2010). "Rising in the East". Genome Biology. 11 (1): 102. doi:10.1186/gb-2010-11-1-102. PMC 2847708. PMID 20156314.
  13. ^ "BGI Americas". BGI. Retrieved 3 December 2018.
  14. ^ "BGI Europe & Africa". BGI. Retrieved 3 December 2018.
  15. ^ "BGI Asia Pacific". BGI. Retrieved 3 December 2018.
  16. ^ "Offices and Laboratories". BGI. Retrieved 3 December 2018.
  17. ^ a b Specter, Michael (6 January 2014) The Gene Factory The New Yorker, Retrieved 28 October 2014
  18. ^ a b Wang Luyao; Han Wei (19 July 2018). "Genome Giant Seeks $1 Billion for Equipment Unit for Potential IPO". Caixin. Retrieved 3 December 2018.
  19. ^ Pharma and Biotech Services Introduction, BGI
  20. ^ BGI - Industry, BGI
  21. ^ David Cyranoski (6 January 2016). "China embraces precision medicine on a massive scale". Nature. Retrieved 2 December 2018.
  22. ^ Rebecca Robbins; Kate Sheridan (26 October 2018). "A Chinese company unveils a powerful new sequencer. But can it compete in the U.S.?". Stat. Retrieved 3 December 2018.
  23. ^ "China's genomics company BGI makes stock market debut". China Daily. 14 July 2017. Retrieved 2 December 2018.
  24. ^ a b c d Li, R.; Fan, W.; Tian, G.; Zhu, H.; He, L.; Cai, J.; Huang, Q.; Cai, Q.; Li, B.; Bai, Y.; Zhang, Z.; Zhang, Y.; Wang, W.; Li, J.; Wei, F.; Li, H.; Jian, M.; Li, J.; Zhang, Z.; Nielsen, R.; Li, D.; Gu, W.; Yang, Z.; Xuan, Z.; Ryder, O. A.; Leung, F. C. C.; Zhou, Y.; Cao, J.; Sun, X.; Fu, Y. (2009). "The sequence and de novo assembly of the giant panda genome". Nature. 463 (7279): 311–317. Bibcode:2010Natur.463..311L. doi:10.1038/nature08696. PMC 3951497. PMID 20010809.
  25. ^ a b Li, R.; Zhu, H.; Ruan, J.; Qian, W.; Fang, X.; Shi, Z.; Li, Y.; Li, S.; Shan, G.; Kristiansen, K.; Li, S.; Yang, H.; Wang, J.; Wang, J. (2009). "De novo assembly of human genomes with massively parallel short read sequencing". Genome Research. 20 (2): 265–272. doi:10.1101/gr.097261.109. PMC 2813482. PMID 20019144.
  26. ^ a b Rasmussen, M.; Li, Y.; Lindgreen, S.; Pedersen, J. S.; Albrechtsen, A.; Moltke, I.; Metspalu, M.; Metspalu, E.; Kivisild, T.; Gupta, R.; Bertalan, M.; Nielsen, K.; Gilbert, M. T. P.; Wang, Y.; Raghavan, M.; Campos, P. F.; Kamp, H. M.; Wilson, A. S.; Gledhill, A.; Tridico, S.; Bunce, M.; Lorenzen, E. D.; Binladen, J.; Guo, X.; Zhao, J.; Zhang, X.; Zhang, H.; Li, Z.; Chen, M.; Orlando, L. (2010). "Ancient human genome sequence of an extinct Palaeo-Eskimo". Nature. 463 (7282): 757–762. Bibcode:2010Natur.463..757R. doi:10.1038/nature08835. PMC 3951495. PMID 20148029.
  27. ^ a b Wang, J.; Wang, W.; Li, R.; Li, Y.; Tian, G.; Goodman, L.; Fan, W.; Zhang, J.; Li, J.; Zhang, J.; Guo, Y.; Feng, B.; Li, H.; Lu, Y.; Fang, X.; Liang, H.; Du, Z.; Li, D.; Zhao, Y.; Hu, Y.; Yang, Z.; Zheng, H.; Hellmann, I.; Inouye, M.; Pool, J.; Yi, X.; Zhao, J.; Duan, J.; Zhou, Y.; Qin, J. (2008). "The diploid genome sequence of an Asian individual". Nature. 456 (7218): 60–65. Bibcode:2008Natur.456...60W. doi:10.1038/nature07484. PMC 2716080. PMID 18987735.
  28. ^ Li, R.; Li, Y.; Zheng, H.; Luo, R.; Zhu, H.; Li, Q.; Qian, W.; Ren, Y.; Tian, G.; Li, J.; Zhou, G.; Zhu, X.; Wu, H.; Qin, J.; Jin, X.; Li, D.; Cao, H.; Hu, X.; Blanche, H. L. N.; Cann, H.; Zhang, X.; Li, S.; Bolund, L.; Kristiansen, K.; Yang, H.; Wang, J.; Wang, J. (2009). "Building the sequence map of the human pan-genome". Nature Biotechnology. 28 (1): 57–63. doi:10.1038/nbt.1596. PMID 19997067.
  29. ^ a b "To Start Building 'Human Pan-Genome,' BGI De Novo Assembles Two Genomes from Illumina Data | In Sequence | Sequencing | GenomeWeb". Retrieved 29 March 2010.
  30. ^ a b c d Aaron Saenz (11 November 2010). "BGI – China's Genomics Center Has A Hand in Everything". Singularity Hub. Singularity University. Retrieved 2 December 2018.
  31. ^ Qin, J.; Li, R.; Raes, J.; Arumugam, M.; Burgdorf, K. S.; Manichanh, C.; Nielsen, T.; Pons, N.; Levenez, F.; Yamada, T.; Mende, D. R.; Li, J.; Xu, J.; Li, S.; Li, D.; Cao, J.; Wang, B.; Liang, H.; Zheng, H.; Xie, Y.; Tap, J.; Lepage, P.; Bertalan, M.; Batto, J. M.; Hansen, T.; Le Paslier, D.; Linneberg, A.; Nielsen, H. B. R.; Pelletier, E.; Renault, P. (2010). "A human gut microbial gene catalogue established by metagenomic sequencing". Nature. 464 (7285): 59–65. Bibcode:2010Natur.464...59.. doi:10.1038/nature08821. PMC 3779803. PMID 20203603.
  32. ^ "International Team Catalogs Microbial Genes in the Human Gut | GenomeWeb Daily News | Sequencing | GenomeWeb". Archived from the original on 7 March 2010. Retrieved 29 March 2010.
  33. ^ Enserink, M. (2003). "SARS IN CHINA: China's Missed Chance". Science. 301 (5631): 294–296. doi:10.1126/science.301.5631.294. PMID 12869735.
  34. ^ German Teams, BGI and Life Technologies Identify Deadly European E.coli Strain, March 23, 2012 | Bio-IT World
  35. ^ a b Xia, Q.; Guo, Y.; Zhang, Z.; Li, D.; Xuan, Z.; Li, Z.; Dai, F.; Li, Y.; Cheng, D.; Li, R.; Cheng, T.; Jiang, T.; Becquet, C.; Xu, X.; Liu, C.; Zha, X.; Fan, W.; Lin, Y.; Shen, Y.; Jiang, L.; Jensen, J.; Hellmann, I.; Tang, S.; Zhao, P.; Xu, H.; Yu, C.; Zhang, G.; Li, J.; Cao, J.; Liu, S. (2009). "Complete Resequencing of 40 Genomes Reveals Domestication Events and Genes in Silkworm (Bombyx)". Science. 326 (5951): 433–436. Bibcode:2009Sci...326..433X. doi:10.1126/science.1176620. PMC 3951477. PMID 19713493.
  36. ^ Cyranoski, D. (2010). "Chinese bioscience: The sequence factory". Nature. 464 (7285): 22–24. doi:10.1038/464022a. PMID 20203579.
  37. ^ Huang, S.; Li, R.; Zhang, Z.; Li, L.; Gu, X.; Fan, W.; Lucas, W.; Wang, X.; Xie, B.; Ni, P.; Ren, Y.; Zhu, H.; Li, J.; Lin, K.; Jin, W.; Fei, Z.; Li, G.; Staub, J.; Kilian, A.; Van Der Vossen, E. A. G.; Wu, Y.; Guo, J.; He, J.; Jia, Z.; Ren, Y.; Tian, G.; Lu, Y.; Ruan, J.; Qian, W.; Wang, M. (2009). "The genome of the cucumber, Cucumis sativus L". Nature Genetics. 41 (12): 1275–1281. doi:10.1038/ng.475. PMID 19881527.
  38. ^ a b "Honors and Awards". BGI. Retrieved 3 December 2018.
  39. ^ "2016 tables: Institutions - corporate (China)". Nature. Retrieved 3 December 2018.
  40. ^ "2016 tables: Institutions - corporate (Global)". Nature. Retrieved 3 December 2018.
  41. ^ "Collaboration surges as businesses outsource discovery to academia". Nature. 6 December 2017. Retrieved 3 December 2018.
  42. ^ a b c d e f g Zhaochen Wang; et al. (2014). "Following the giant's paces-governance issues and bioethical reflections in China". BMC Med Ethics. 15. doi:10.1186/1472-6939-15-79.
  43. ^ Shukman, David (14 January 2014) China cloning on an 'industrial scale' BBC News Science and Environment, Retrieved 14 January 2014
  44. ^ "Breaking News: BGI Launches Two Important Global Plans at JP Morgan Healthcare Conference". genomics.cn. BGI. 11 January 2018. Retrieved 2 December 2018.
  45. ^ "Chinese scientists sequence 1st volunteer's genome". People's Daily Online. 7 January 2008. Retrieved 29 October 2014.
  46. ^ a b Qiu, Jane; Hayden, Check (2008). "Genomics sizes up". Nature. 451 (7176): 234. Bibcode:2008Natur.451..234Q. doi:10.1038/451234a. PMID 18202611.
  47. ^ a b "BGI Offers Next-Gen Sequencing Service, Kicks Off 100-Genome Sequencing Project | In Sequence | Sequencing | GenomeWeb". Genomeweb LLC. 8 January 2008. Retrieved 29 October 2014. (Subscription required (help)).
  48. ^ (20 November 2008) TuanHuang - The First Asian Diploid Genome BGI Shenzen web page, Retrieved 29 October 2014
  49. ^ a b "BGI Announces New Partnerships and 8th Anniversary Milestone in US". BGI. 4 May 2018. Retrieved 3 December 2018.
  50. ^ a b Ed Yong (14 May 2013). "Chinese project probes the genetics of genius". Nature. 497 (7449): 297–299. doi:10.1038/497297a.
  51. ^ Jason Dorrier (19 March 2013). "China's BGI to Sequence 2,200 Geniuses In Search For "Smart" Genes". Singularity Hub. Singularity University. Retrieved 3 December 2018.
  52. ^ "BGI Seeks Proposals to Sequence 1,000 Plant, Animal Genomes; Pledges $100M Toward Effort". GenomeWeb. 12 January 2010. Retrieved 3 December 2018.
  53. ^ "Genome projects launched for three extreme-environment animals". 26 April 2009. Retrieved 22 May 2015.
  54. ^ "BGI to Sequence Tiger, Lion, and Leopard Species This Year | In Sequence | Sequencing | GenomeWeb". Archived from the original on 28 February 2010. Retrieved 29 March 2010.
  55. ^ "BGI". Archived from the original on 17 February 2010. Retrieved 29 March 2010.
  56. ^ Cho, Y. S.; Hu, L.; Hou, H.; Lee, H.; Xu, J.; Kwon, S.; Oh, S.; Kim, H. M.; Jho, S.; Kim, S.; Shin, Y. A.; Kim, B. C.; Kim, H.; Kim, C. U.; Luo, S. J.; Johnson, W. E.; Koepfli, K. P.; Schmidt-Küntzel, A.; Turner, J. A.; Marker, L.; Harper, C.; Miller, S. M.; Jacobs, W.; Bertola, L. D.; Kim, T. H.; Lee, S.; Zhou, Q.; Jung, H. J.; Xu, X.; et al. (2013). "The tiger genome and comparative analysis with lion and snow leopard genomes". Nature Communications. 4: 2433. Bibcode:2013NatCo...4E2433C. doi:10.1038/ncomms3433. PMC 3778509. PMID 24045858.
  57. ^ "BGI". Archived from the original on 21 August 2010. Retrieved 29 March 2010.
  58. ^ "10,000 Microbe Genome Plan Starts in Shenzhen". Chinese Academy of Sciences. 5 August 2009. Archived from the original on 25 September 2010. Retrieved 2 December 2018.
  59. ^ "BGI Uses New Short-Read Algorithm to Assemble Panda Genome as Proof of Concept for Human Genome | BioInform | Informatics | GenomeWeb". Retrieved 28 March 2010.
  60. ^ a b "BGI Retools Complete Genomics Technology for Its New High-Throughput Benchtop Sequencer". Bio-ITWorld. Cambridge Healthtech Institute. 28 October 2015. Retrieved 2 December 2018.
  61. ^ a b c "BGI Launches New Desktop Sequencer in China, Registers Larger Version With CFDA". 360Dx. GenomeWeb. 11 November 2016. Retrieved 2 December 2018.
  62. ^ Julia Karow (26 October 2015). "BGI Launches Desktop Sequencer in China; Plans to Register Platform With CFDA". GenomeWeb. Retrieved 2 December 2018.
  63. ^ Monica Heger (21 September 2016). "China National GeneBank Opens With Investments From BGI, Government". GenomeWeb. Retrieved 2 December 2018.
  64. ^ Monica Heger (26 October 2018). "BGI Launches New Sequencer as Customers Report Data From Earlier Instruments". GenomeWeb. Retrieved 2 December 2018.
  65. ^ "BGI's MGI Tech Launches Two New NGS Platforms". PR Newswire. 31 October 2017. Retrieved 3 December 2018.
  66. ^ "MGI Introduces Groundbreaking Ultra-High-Throughput Sequencer, MGISEQ-T7". PR Newswire. 27 October 2018. Retrieved 3 December 2018.

External links[edit]