The duo recorded their first record How You Luv That in 1997 featuring all of the rappers on Cash Money Records including B.G. and Juvenile. How You Luv That reached a peak of No. 25 of the R&B/hip hop chart and the lower reaches of the Billboard 200. The remixed version How You Luv That Vol. 2 almost reached the top 100 of the Billboard album chart and reached the top 20 of the Billboard R&B and hip hop chart.
Their second album I Got That Work released in 2000 reached the top 5 of the US album chart and topped the US R&B/hip hop chart. This album spawned two big hits in "Get Your Roll On" and "#1 Stunna" reaching the top 30 on the R&B singles charts.
Hood Rich released in 2002 topped both the US album and R&B charts. "Still Fly" from the album reached the top 20 on the R&B singles charts and No. 11 on the pop charts. "Oh Yeah" reached the top 50 of the Billboard Hot 100 and the top 30 of the R&B/hip hop charts.
Big Money Heavyweight in 2003 was not as successful reaching No. 21 on the album charts and top ten in the R&B charts. A remix album made the lower reaches of the R&B/hip hop charts in 2004. "Gangsta Girl" from the album made the lower reaches of the Billboard Hot 100 and the top 40 of the R&B charts.
As of May 2013, Birdman, Lil Wayne and Drake have been in talks of restarting the group with an upcoming album, while original member Mannie Fresh would not be included. While doing promotion for the Rich Gang Birdman indicated that a Big Tymers' single would be released in September or October 2013, with a possibility that Mannie Fresh would also be involved with the album. It is now unlikely a Big Tymers' project will be released, due to the fading relationship between Birdman and Lil Wayne.