C1QBP

C1QBP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1P32, 3RPX
Identifiers
Aliases	C1QBP, GHABP1, SF2p32, gC1Q-R, gC1qR, p32, complement component 1, q subcomponent binding protein, complement C1q binding protein, COXPD33, SF2AP32
External IDs	OMIM: 601269; MGI: 1194505; HomoloGene: 31023; GeneCards: C1QBP; OMA:C1QBP - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	5,448,830 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	70,873,852 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; right adrenal gland; ; rectum; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; islet of Langerhans; ; mucosa of esophagus; ; anterior pituitary; ; gastrocnemius muscle;
	Top expressed in
	primitive streak; ; endothelial cell of lymphatic vessel; ; condyle; ; Paneth cell; ; hair follicle; ; fossa; ; fetal liver hematopoietic progenitor cell; ; otic placode; ; facial motor nucleus; ; medial ganglionic eminence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transcription corepressor activity; transcription factor binding; protein binding; hyaluronic acid binding; kininogen binding; mitochondrial ribosome binding; mRNA binding; protein kinase C binding; complement component C1q complex binding; adrenergic receptor binding; translation activator activity;
Cellular component	cytosol; extracellular region; cell surface; mitochondrial matrix; nucleolus; cytoplasm; membrane; mitochondrion; nucleus; extracellular space; plasma membrane; presynaptic active zone; presynapse; glutamatergic synapse; GABA-ergic synapse;
Biological process	blood coagulation, intrinsic pathway; positive regulation of mitochondrial translation; negative regulation of interferon-gamma production; positive regulation of protein kinase B signaling; negative regulation of MDA-5 signaling pathway; regulation of transcription, DNA-templated; adaptive immune response; ribosome biogenesis; negative regulation of defense response to virus; immune system process; mRNA processing; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; positive regulation of trophoblast cell migration; positive regulation of substrate adhesion-dependent cell spreading; mature ribosome assembly; negative regulation of mRNA splicing, via spliceosome; immune response; RNA splicing; positive regulation of neutrophil chemotaxis; complement activation, classical pathway; positive regulation of apoptotic process; phosphatidylinositol 3-kinase signaling; innate immune response; viral process; positive regulation of dendritic cell chemotaxis; regulation of complement activation; negative regulation of RIG-I signaling pathway; positive regulation of cell adhesion; negative regulation of interleukin-12 production; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	708
	12261
	ENSG00000108561
	ENSMUSG00000018446
	Q07021
	O35658; Q8R5L1
	NM_001212
	NM_007573
	NP_001203
	NP_031599
	Wikidata
View/Edit Human	View/Edit Mouse

Complement component 1 Q subcomponent-binding protein, mitochondrial is a protein that in humans is encoded by the C1QBP gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

C1QBP has been shown to interact with Protein kinase D1,^[8] BAT2,^[9] PRKCD,^[8] PKC alpha^[8] and Protein kinase Mζ.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000108561 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018446 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Deb TB, Datta K (March 1996). "Molecular cloning of human fibroblast hyaluronic acid-binding protein confirms its identity with P-32, a protein co-purified with splicing factor SF2. Hyaluronic acid-binding protein as P-32 protein, co-purified with splicing factor SF2". J Biol Chem. 271 (4): 2206–12. doi:10.1074/jbc.271.4.2206. PMID 8567680.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Ghebrehiwet B, Lim BL, Peerschke EI, Willis AC, Reid KB (June 1994). "Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of C1q". J Exp Med. 179 (6): 1809–21. doi:10.1084/jem.179.6.1809. PMC 2191527. PMID 8195709.
^ "Entrez Gene: C1QBP complement component 1, q subcomponent binding protein".
^ ^a ^b ^c ^d Storz, P; Hausser A; Link G; Dedio J; Ghebrehiwet B; Pfizenmaier K; Johannes F J (August 2000). "Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32". J. Biol. Chem. 275 (32). UNITED STATES: 24601–7. doi:10.1074/jbc.M002964200. ISSN 0021-9258. PMID 10831594. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ Lehner, Ben; Semple Jennifer I; Brown Stephanie E; Counsell Damian; Campbell R Duncan; Sanderson Christopher M (January 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1). United States: 153–67. doi:10.1016/S0888-7543(03)00235-0. ISSN 0888-7543. PMID 14667819. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

External links

Human C1QBP genome location and C1QBP gene details page in the UCSC Genome Browser.

Template:PBB Controls

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000108561 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018446 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8567680-5] Deb TB, Datta K (March 1996). "Molecular cloning of human fibroblast hyaluronic acid-binding protein confirms its identity with P-32, a protein co-purified with splicing factor SF2. Hyaluronic acid-binding protein as P-32 protein, co-purified with splicing factor SF2". J Biol Chem. 271 (4): 2206–12. doi:10.1074/jbc.271.4.2206. PMID 8567680.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[pmid8195709-6] Ghebrehiwet B, Lim BL, Peerschke EI, Willis AC, Reid KB (June 1994). "Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular "heads" of C1q". J Exp Med. 179 (6): 1809–21. doi:10.1084/jem.179.6.1809. PMC 2191527. PMID 8195709.

[entrez-7] "Entrez Gene: C1QBP complement component 1, q subcomponent binding protein".

[pmid10831594-8] Storz, P; Hausser A; Link G; Dedio J; Ghebrehiwet B; Pfizenmaier K; Johannes F J (August 2000). "Protein kinase C [micro] is regulated by the multifunctional chaperon protein p32". J. Biol. Chem. 275 (32). UNITED STATES: 24601–7. doi:10.1074/jbc.M002964200. ISSN 0021-9258. PMID 10831594. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

[pmid14667819-9] Lehner, Ben; Semple Jennifer I; Brown Stephanie E; Counsell Damian; Campbell R Duncan; Sanderson Christopher M (January 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1). United States: 153–67. doi:10.1016/S0888-7543(03)00235-0. ISSN 0888-7543. PMID 14667819. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

Interactions

References

Further reading

External links