Coenzyme F420-1:gamma-L-glutamate ligase

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Coenzyme F420-1:gamma-L-glutamate ligase
Identifiers
EC number 6.3.2.34
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Coenzyme F420-1:gamma-L-glutamate ligase (EC 6.3.2.34, F420:gamma-glutamyl ligase, CofE-AF, MJ0768, CofE) is an enzyme with systematic name L-glutamate:coenzyme F420-1 ligase (GDP-forming).[1][2] This enzyme catalyses the following chemical reaction

GTP + coenzyme F420-1 + L-glutamate GDP + phosphate + coenzyme gamma-F420-2

This protein catalyses the successive addition of two glutamate residues to cofactor F420 by two distinct and independent reactions. I

References[edit]

  1. ^ Li, H.; Graupner, M.; Xu, H.; White, R.H. (2003). "CofE catalyzes the addition of two glutamates to F420-0 in F420 coenzyme biosynthesis in Methanococcus jannaschii". Biochemistry. 42: 9771–9778. PMID 12911320. doi:10.1021/bi034779b. 
  2. ^ Nocek, B.; Evdokimova, E.; Proudfoot, M.; Kudritska, M.; Grochowski, L.L.; White, R.H.; Savchenko, A.; Yakunin, A.F.; Edwards, A.; Joachimiak, A. (2007). "Structure of an amide bond forming F420:γ-glutamyl ligase from Archaeoglobus fulgidus — a member of a new family of non-ribosomal peptide synthases". J. Mol. Biol. 372: 456–469. PMC 2678844Freely accessible. PMID 17669425. doi:10.1016/j.jmb.2007.06.063. 

External links[edit]