Crotonyl-CoA carboxylase/reductase

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Crotonyl-CoA carboxylase/reductase
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Crotonyl-CoA carboxylase/reductase tetramer, Streptomyces sp. NRRL 2288
Identifiers
EC number1.3.1.85
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Crotonyl-CoA carboxylase/reductase (EC 1.3.1.85, CCR, crotonyl-CoA reductase (carboxylating)) is an enzyme with systematic name (2S)-ethylmalonyl-CoA:NADP+ oxidoreductase (decarboxylating).[1][2] This enzyme catalyses the following chemical reaction

(2S)-ethylmalonyl-CoA + NADP+ (E)-but-2-enoyl-CoA + CO2 + NADPH + H+

The reaction is catalysed in the reverse direction.

References[edit]

  1. ^ Erb, T.J.; Berg, I.A.; Brecht, V.; Muller, M.; Fuchs, G.; Alber, B.E. (2007). "Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway". Proc. Natl. Acad. Sci. USA. 104: 10631–10636. doi:10.1073/pnas.0702791104. PMC 1965564. PMID 17548827.
  2. ^ Erb, T.J.; Brecht, V.; Fuchs, G.; Muller, M.; Alber, B.E. (2009). "Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase". Proc. Natl. Acad. Sci. USA. 106: 8871–8876. doi:10.1073/pnas.0903939106. PMC 2689996. PMID 19458256.

External links[edit]