Crotonyl-CoA carboxylase/reductase tetramer, Streptomyces sp. NRRL 2288
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Crotonyl-CoA carboxylase/reductase (EC 188.8.131.52, CCR, crotonyl-CoA reductase (carboxylating)) is an enzyme with systematic name (2S)-ethylmalonyl-CoA:NADP+ oxidoreductase (decarboxylating). This enzyme catalyses the following chemical reaction
- (2S)-ethylmalonyl-CoA + NADP+ (E)-but-2-enoyl-CoA + CO2 + NADPH + H+
The reaction is catalysed in the reverse direction.
- Erb TJ, Berg IA, Brecht V, Müller M, Fuchs G, Alber BE (June 2007). "Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway". Proceedings of the National Academy of Sciences of the United States of America. 104 (25): 10631–6. doi:10.1073/pnas.0702791104. PMC 1965564. PMID 17548827.
- Erb TJ, Brecht V, Fuchs G, Müller M, Alber BE (June 2009). "Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase". Proceedings of the National Academy of Sciences of the United States of America. 106 (22): 8871–6. doi:10.1073/pnas.0903939106. PMC 2689996. PMID 19458256.