DVL3

DVL3
Identifiers
Aliases	DVL3, DRS3, dishevelled segment polarity protein 3
External IDs	OMIM: 601368; MGI: 108100; HomoloGene: 20928; GeneCards: DVL3; OMA:DVL3 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	184,173,614 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	20,352,760 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; ganglionic eminence; ; gastric mucosa; ; muscle layer of sigmoid colon; ; body of uterus; ; apex of heart; ; sural nerve; ; right ovary; ; left uterine tube; ; left ovary;
	Top expressed in
	cardiac muscle tissue of left ventricle; ; external carotid artery; ; internal carotid artery; ; genital tubercle; ; choroid plexus of fourth ventricle; ; trigeminal ganglion; ; tail of embryo; ; molar; ; ventricular zone; ; zygote;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	beta-catenin binding; frizzled binding; protease binding; protein binding; protein heterodimerization activity; signaling receptor binding;
Cellular component	cytoplasm; cytosol;
Biological process	positive regulation of protein phosphorylation; intracellular signal transduction; positive regulation of JUN kinase activity; protein stabilization; Wnt signaling pathway; positive regulation of transcription, DNA-templated; multicellular organism development; positive regulation of GTPase activity; negative regulation of canonical Wnt signaling pathway; beta-catenin destruction complex disassembly; non-canonical Wnt signaling pathway; non-canonical Wnt signaling pathway via JNK cascade; canonical Wnt signaling pathway; Wnt signaling pathway, planar cell polarity pathway; planar cell polarity pathway involved in neural tube closure; positive regulation of neuron projection arborization;
	Sources:Amigo / QuickGO
Orthologs
	1857
	13544
	ENSG00000161202
	ENSMUSG00000003233
	Q92997
	Q61062
	NM_004423
	NM_007889; NM_001347176
	NP_004414
	NP_001334105; NP_031915
	Wikidata
View/Edit Human	View/Edit Mouse

Segment polarity protein dishevelled homolog DVL-3 is a protein that in humans is encoded by the DVL3 gene.^[5]^[6]

Template:PBB Summary

Interactions

DVL3 has been shown to interact with DAB2,^[7] DVL1^[8] and PRPF3.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000161202 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003233 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pizzuti A, Amati F, Calabrese G, Mari A, Colosimo A, Silani V, Giardino L, Ratti A, Penso D, Calza L, Palka G, Scarlato G, Novelli G, Dallapiccola B (January 1997). "cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene". Hum Mol Genet. 5 (7): 953–8. doi:10.1093/hmg/5.7.953. PMID 8817329.
^ "Entrez Gene: DVL3 dishevelled, dsh homolog 3 (Drosophila)".
^ Hocevar, B A; Mou F; Rennolds J L; Morris S M; Cooper J A; Howe P H (June 2003). "Regulation of the Wnt signaling pathway by disabled-2 (Dab2)". EMBO J. 22 (12). England: 3084–94. doi:10.1093/emboj/cdg286. ISSN 0261-4189. PMC 162138. PMID 12805222. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Kishida, S; Yamamoto H; Hino S; Ikeda S; Kishida M; Kikuchi A (June 1999). "DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability". Mol. Cell. Biol. 19 (6). UNITED STATES: 4414–22. doi:10.1128/mcb.19.6.4414. ISSN 0270-7306. PMC 104400. PMID 10330181. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). England: 1173–8. doi:10.1038/nature04209. PMID 16189514. {{cite journal}}: Cite has empty unknown parameters: |laysource=, |laysummary=, and |laydate= (help)

DVL3

Interactions

See also

References

Further reading