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Daniel O. Griffin

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Daniel O. Griffin

Daniel O’Connell Griffin (born 15 July 1967) is an American infectious disease specialist. He is president of the nonprofit organization Parasites Without Borders.[1]

Co-director of Life Science podcast network Microbe.TV,[2] Griffin broadcasts a weekly COVID Clinical Update[3] as part of This Week in Virology (TWiV) podcasts.

Griffin co-authored the textbook Parasitic Diseases (7th edition 2019),[4][5] available in more than 100 countries. In 2017, he published the paper Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+CD27+CD43+CD70[6] in the Journal of Experimental Medicine. He is senior fellow in infectious disease at United Health Group,[7] Instructor in Clinical Medicine, Columbia University Irving Medical Centre, and Infectious Disease Clinician Chief, Pro Health Care.[8]

Education

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Griffin earned his BA in Philosophy from the University of Colorado Boulder in 1989.[9][10] He received his MD degree[11] from New York University School of Medicine and completed an internal medicine residency at the University of Utah.[11] He completed a PhD in Molecular medicine from the Elmezzi Graduate School of Molecular Medicine, Manhasset, New York in 2012.[12] In 2014, he completed a fellowship in infectious diseases from North Shore-Long Island Jewish Health System-Hofstra University in Manhasset.[13]

Research and career

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Griffin's work includes investigating the potential role of human B1 cells and natural antibodies in the development of HIV-associated malignancies.[11][14] He has a special focus on HIV and tropical medicine.[15] His research interests are broad and include studies on infectious disease and immunology, molecular medicine, and tropical medicine.[citation needed] As of 2021, his research focused on HIV-1, stem cell latency, stem cell gene therapy using retroviral vectors, and COVID-19.[16][17]

Griffin has volunteered with the nonprofit Foundation for International Medical Relief of Children, including conducting mandatory health education sessions for its staff.[18][19][20] He joined the biomedical research community of the Vagelos College of Physicians and Surgeons of Columbia University.[citation needed] He is an associate research scientist in Columbia's Department of Biochemistry and Molecular Biophysics, instructor of clinical medicine, and a member of the division of infectious diseases.[21][11]

Science communication

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Griffin co-authored at least two editions of a textbook on parasitology, Parasitic Diseases, with Dickson Despommier.[22] The two men decided to found the nonprofit organization Parasites Without Borders to disseminate clinical information about parasitic disease, including the textbook.[23][24][22][25] As of June 2021, 40,000 copies had been distributed to over 100 countries.[25]

Since episode 80 of the monthly podcast This Week in Parasitism (TWiP), Griffin has been its co-host with Racaniello and Despommier.[26]

In early March 2020 as the COVID-19 pandemic began to seriously affect the New York City area, Griffin began providing clinical updates about the virus based on his practice and correspondence with medical colleagues around the world on another podcast hosted by Racaniello, This Week in Virology (TWiV).[27] Eventually the popularity of the clinical updates resulted in Racaniello publishing them in standalone episodes of TWiV.[28] As of May 2022, Griffin had provided 112 such clinical updates on TWiV.[3]

Affiliations

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Griffin is a member in the following scientific societies or associations:

Patents

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  • Human B1 cells and uses thereof.[31]

Awards

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  • Ruth and Leonard Litwin Fellowship Award in 2011 [32]
  • Davies Award in 2006 (An international award given by HIMSS, the largest health IT organization in the world) [33]

Selected publications

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  • Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+CD27+CD43+CD70− [34]
  • Identifying Optimal COVID-19 Testing Strategies for School and Businesses: Balancing testing frequency, individual test technology, and cost [35]
  • Human B-1 cells take the stage [14]
  • A small CD11b+ human B1 cell subpopulation stimulates T cells and is expanded in lupus.[36]
  • Human “orchestrator” CD11b+ B1 cells spontaneously secrete interleukin-10 and regulate T-cell activity.[37]
  • Human B1 cell frequency: isolation and analysis of human B1 cells [38]
  • Human B1 cells are CD3−: A reply to “A human equivalent of mouse B-1 cells?” and “The nature of circulating CD27+CD43+ B cells” [39]
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References

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  1. ^ "Education for Parasitic Diseases | Parasites Without Borders". parasiteswithoutborders.com. 5 February 2020. Retrieved 2022-05-02.
  2. ^ "The Latest Podcasts in the Microbe.TV Network". 2015-12-01. Retrieved 2022-05-02.
  3. ^ a b "TWiV 895: COVID-19 clinical update #112 with Dr. Daniel Griffin". 2022-04-30. Retrieved 2022-05-02.
  4. ^ Griffin, Daniel; Gwadz, Robert; DESPOMMIER, DICKSON; Hotez, Peter; Knirsch, Charles (2017-03-25). Parasitic Diseases 6th Edition. Independently Published. ISBN 978-1-5208-8997-9.
  5. ^ ecropolis (2020-02-05). "Books | Parasites without Borders". Retrieved 2022-05-02.
  6. ^ Griffin, Daniel O.; Holodick, Nichol E.; Rothstein, Thomas L. (2011-01-17). "Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+CD27+CD43+CD70−". The Journal of Experimental Medicine. 208 (1): 67–80. doi:10.1084/jem.20101499. ISSN 0022-1007. PMC 3023138. PMID 21220451.
  7. ^ "Antibody Research & Treatment: How We're Fighting COVID-19". www.unitedhealthgroup.com. Retrieved 2022-05-02.
  8. ^ "Daniel Griffin, MD". www.prohealthcare.com. Retrieved 2022-05-02.
  9. ^ "Notes from the Class of 1989". Alumni Association. Retrieved 2022-05-01.
  10. ^ ecropolis (2020-02-05). "Daniel Griffin, MD, PhD | Parasites without Borders". Retrieved 2022-05-01.
  11. ^ a b c d e "Daniel Griffin, M.D., Ph.D." ASM.org. Retrieved 2022-05-01.
  12. ^ "Elmezzi Graduate School of Molecular Medicine". The Elmezzi Foundation. Retrieved 2022-05-01.
  13. ^ "Dr. Daniel Griffin, MD – Lake Success, NY | Infectious Disease on Doximity". Doximity. Retrieved 2021-02-04.
  14. ^ a b Rothstein, Thomas L.; Griffin, Daniel O.; Holodick, Nichol E.; Quach, Tam D.; Kaku, Hiroaki (May 2013). "Human B-1 cells take the stage". Annals of the New York Academy of Sciences. 1285 (1): 97–114. Bibcode:2013NYASA1285...97R. doi:10.1111/nyas.12137. ISSN 1749-6632. PMC 4429725. PMID 23692567.
  15. ^ "Bio". www.diabetestechnology.org. Retrieved 2021-02-04.
  16. ^ Ngo, Binh T.; Marik, Paul; Kory, Pierre; Shapiro, Leland; Thomadsen, Raphael; Iglesias, Jose; Ditmore, Stephen; Rendell, Marc; Varon, Joseph; Dubé, Michael; Nanda, Neha (2021-01-23). "The time to offer treatments for COVID-19". pp. 505–518. medRxiv 10.1101/2020.05.27.20115238v9.
  17. ^ Griffin, Daniel O.; Rothstein, Thomas L. (2012). "Human b1 cell frequency: isolation and analysis of human b1 cells". Frontiers in Immunology. 3: 122. doi:10.3389/fimmu.2012.00122. ISSN 1664-3224. PMC 3360193. PMID 22654880.
  18. ^ "Parasites Without Borders Creates Pop-Up Fundraiser for FIMRC". www.fimrc.org. Retrieved 2022-05-01.
  19. ^ "Uganda Volunteer". www.fimrc.org. Retrieved 2022-05-01.
  20. ^ "Celebrating World NTD Day". www.fimrc.org. Retrieved 2022-05-01.
  21. ^ "Columbia University: Directory". directory.columbia.edu. Retrieved 2022-05-01.
  22. ^ a b Rosenthal, Philip J. (2018-03-07). "Book Review". The American Journal of Tropical Medicine and Hygiene. 98 (3): 933–934. doi:10.4269/ajtmh.17-1003. ISSN 0002-9637. PMC 5930926.
  23. ^ Borders, Parasites Without. "Directors of Parasites Without Borders Helping Fight COVID-19". www.prnewswire.com (Press release). Retrieved 2022-05-01.
  24. ^ "Parasites Without Borders Inc". IRS. 1 May 2022. Retrieved 1 May 2022.
  25. ^ a b "ASTMH - Q&A with Parasites Without Borders". www.astmh.org. Retrieved 2022-05-02.
  26. ^ "TWiP 80: Daniel in the parasites' den | This Week in Parasitism". 2015-01-08. Retrieved 2022-05-02.
  27. ^ "TWiV Special: Coronavirus SARS-CoV-2 and COVID-19 update | This Week in Virology". 2020-03-05. Retrieved 2022-05-02.
  28. ^ "TWiV 686: COVID-19 clinical update #38 with Dr. Daniel Griffin | This Week in Virology". 2020-11-28. Retrieved 2022-05-02.
  29. ^ "2016 Cerficiate of Tropical Medicine Recipients" (PDF). American Society of Tropical Medicine and Hygiene. 2 May 2022. Retrieved 2 May 2022.
  30. ^ "The International Society of Travel Medicine". www.istm.org. Retrieved 2022-05-02.
  31. ^ CA 2812416, Rothstein, Thomas L.; Griffin, Daniel O. & Holodick, Nichol E., "Human B1 cells and uses thereof", published 2012-03-29, issued 2011-09-22, assigned to The Feinstein Institute for Medical Research 
  32. ^ "Northwell Health Foundation". support.northwell.edu. Retrieved 2021-02-04.
  33. ^ "Daniel Griffin, MD, HIMSS 2006 Davies award for excellence in Electronic Medical Records | EMR Software | Praxis EMR, EHR Software". www.praxisemr.com. Retrieved 2021-02-04.
  34. ^ Griffin, Daniel O.; Holodick, Nichol E.; Rothstein, Thomas L. (2011-01-17). "Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+CD27+CD43+CD70−". Journal of Experimental Medicine. 208 (1): 67–80. doi:10.1084/jem.20101499. ISSN 0022-1007. PMC 3023138. PMID 21220451.
  35. ^ Lyng, Gregory D.; Sheils, Natalie E.; Kennedy, Caleb J.; Griffin, Daniel; Berke, Ethan M. (2020-10-12). "Identifying Optimal COVID-19 Testing Strategies for Schools and Businesses: Balancing Testing Frequency, Individual Test Technology, and Cost". medRxiv 10.1101/2020.10.11.20211011v2.
  36. ^ Griffin, Daniel O.; Rothstein, Thomas L. (2011-12-19). "A small CD11b+ human B1 cell subpopulation stimulates T cells and is expanded in lupus". Journal of Experimental Medicine. 208 (13): 2591–2598. doi:10.1084/jem.20110978. ISSN 0022-1007. PMC 3244038. PMID 22110167.
  37. ^ Griffin, Daniel O.; Rothstein, Thomas L. (June 2012). "Human "Orchestrator" CD11b + B1 Cells Spontaneously Secrete Interleukin-10 and Regulate T-Cell Activity". Molecular Medicine. 18 (6): 1003–1008. doi:10.2119/molmed.2012.00203. ISSN 1528-3658. PMC 3459484. PMID 22634719.
  38. ^ Griffin, Daniel; Rothstein, Thomas L. (2012). "Human B1 Cell Frequency: Isolation and Analysis of Human B1 Cells". Frontiers in Immunology. 3: 122. doi:10.3389/fimmu.2012.00122. ISSN 1664-3224. PMC 3360193. PMID 22654880.
  39. ^ Griffin, Daniel O.; Holodick, Nichol E.; Rothstein, Thomas L. (2011-12-19). "Human B1 cells are CD3−: A reply to "A human equivalent of mouse B-1 cells?" and "The nature of circulating CD27+CD43+ B cells"". Journal of Experimental Medicine. 208 (13): 2566–2569. doi:10.1084/jem.20111761. ISSN 0022-1007. PMC 3244032. PMID 22184682.
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