Dihydropyrimidine dehydrogenase
 |
| dihydropyrimidine dehydrogenase | |
|---|---|
| Identifiers | |
| Symbol | DPYD |
| NCBI gene | 1806 |
| HGNC | 3012 |
| OMIM | 274270 |
| RefSeq | NM_000110 |
| Other data | |
| EC number | 1.3.1.2 |
| Locus | Chr. 1 p22 |
Dihydropyrimidine dehydrogenase (DPD) is an enzyme that is involved in pyrimidine degradation. It is the initial and rate-limiting step in pyrimidine catabolism. It catalyzes the reduction of uracil and thymine. It is also involved in the degradation of the chemotherapeutic drugs 5-fluorouracil and Tegafur-uracil.
See also
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