Distal splenorenal shunt procedure
|Distal splenorenal shunt procedure|
3D rendered CT of abdominal aortic branches and kidneys, to show relative position of veins. Splenic vein and left renal vein labeled at center right.
In medicine, a distal splenorenal shunt procedure (DSRS), also splenorenal shunt procedure and Warren shunt, is a surgical procedure in which the distal splenic vein (a part of the portal venous system) is attached to the left renal vein (a part of the systemic venous system). It is used to treat portal hypertension and its main complication (esophageal varices). It was developed by W. Dean Warren.
Splenopancreatic and gastric disconnection (SPGD)
DSRS is typically done with splenopancreatic and gastric disconnection (ligation of the gastric veins and pancreatic veins (that drain into the portal vein) and complete detachment of the splenic vein from the portal venous system), as it improves the outcome.
Comparison to TIPS
Both TIPS and DSRS lead to decreased rates of variceal bleeding at the expense of hepatic encephalopathy; however, TIPS appears to have more shunt dysfunction and lead to more encephalopathy and bleeds. DSRS appears to be more cost effective than TIPS.
- Warren WD, Henderson JM, Millikan WJ, Galambos JT, Brooks WS, Riepe SP, Salam AA, Kutner MH (May 1986). "Distal splenorenal shunt versus endoscopic sclerotherapy for long-term management of variceal bleeding. Preliminary report of a prospective, randomized trial". Ann. Surg. 203 (5): 454–62. doi:10.1097/00000658-198605000-00002. PMC 1251141. PMID 3486641.
- Boyer TD, Kokenes DD, Hertzler G, Kutner MH, Henderson JM (December 1994). "Effect of distal splenorenal shunt on survival of patients with primary biliary cirrhosis". Hepatology. 20 (6): 1482–6. doi:10.1002/hep.1840200617. PMID 7982648.
- Hirano S, Kondo S, Ambo Y, Tanaka E, Morikawa T, Okushiba S, Katoh H (2005). "Appraisal of DSRS with SPGD for esophagogastric varices: a retrospective comparative study according to the underlying liver diseases". Hepatogastroenterology. 52 (61): 152–5. PMID 15783017.
- Rockey, DC. "Update on the Role of TIPS in the Management of Portal Hypertension". Medscape. WebMD LLC. Retrieved March 18, 2006. (Registration required (help)).
- Khan S, Tudur Smith C, Williamson P, Sutton R (October 2006). "Portosystemic shunts versus endoscopic therapy for variceal rebleeding in patients with cirrhosis". Cochrane Database Syst Rev (4): CD000553. doi:10.1002/14651858.CD000553.pub2. PMID 17054131.
- "Multicenter, Randomized Trial of DSRS vs. TIPS". University of Wisconsin- Madison, General Surgery.
- Henderson JM, Boyer TD, Kutner MH, Galloway JR, Rikkers LF, Jeffers LJ, Abu-Elmagd K, Connor J (May 2006). "Distal splenorenal shunt versus transjugular intrahepatic portal systematic shunt for variceal bleeding: a randomized trial". Gastroenterology. 130 (6): 1643–51. doi:10.1053/j.gastro.2006.02.008. PMID 16697728.
- Zacks SL, Sandler RS, Biddle AK, Mauro MA, Brown RS (May 1999). "Decision-analysis of transjugular intrahepatic portosystemic shunt versus distal splenorenal shunt for portal hypertension". Hepatology. 29 (5): 1399–405. doi:10.1002/hep.510290512. PMID 10216122.