Epstein–Barr virus nuclear antigen 2

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The Epstein–Barr virus nuclear antigen 2 (EBNA-2) is a viral protein[which?] associated with the Epstein–Barr virus.[1]

EBNA-2 is the main viral transactivator, switching transcription from the Wp promoters[clarification needed] initially used after infection to the Cp promoter.[clarification needed] Together with EBNA-3C,[clarification needed] it also activates the LMP-1 promoter.[clarification needed] It is known to bind the host RBP-Jκ protein[clarification needed] that is a key player in the Notch pathway. EBNA-2 is essential for EBV-mediated growth transformation.[citation needed]


  1. ^ Palermo RD, Webb HM, Gunnell A, West MJ (August 2008). "Regulation of transcription by the Epstein-Barr virus nuclear antigen EBNA 2". Biochem. Soc. Trans. 36 (Pt 4): 625–8. doi:10.1042/BST0360625. PMID 18631129.