FKBP1B

FKBP1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1C9H, 3J8E, 4C02, 4IQ2, 4IQC
Identifiers
Aliases	FKBP1B, FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase, FK506 binding protein 1B, FKBP prolyl isomerase 1B
External IDs	OMIM: 600620 MGI: 1336205 HomoloGene: 68380 GeneCards: FKBP1B
Gene location (Human)
Chr.	Chromosome 2 (human)
End	24,063,681 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	4,891,591 bp
RNA expression pattern
	Top expressed in
	nucleus accumbens; ; caudate nucleus; ; putamen; ; hippocampus proper; ; temporal lobe; ; amygdala; ; dorsolateral prefrontal cortex; ; superior frontal gyrus; ; Brodmann area 9; ; prefrontal cortex;
	Top expressed in
	trigeminal ganglion; ; barrel cortex; ; spinal ganglia; ; islet of Langerhans; ; facial motor nucleus; ; motor neuron; ; substantia nigra; ; medulla oblongata; ; pontine nuclei; ; medial vestibular nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	ryanodine-sensitive calcium-release channel activity; calcium channel inhibitor activity; transmembrane transporter binding; FK506 binding; isomerase activity; peptidyl-prolyl cis-trans isomerase activity; protein binding; signaling receptor binding; cyclic nucleotide binding;
Cellular component	cytoplasm; calcium channel complex; intracellular membrane-bounded organelle; membrane; sarcoplasmic reticulum; Z disc; sarcoplasmic reticulum membrane; cytosol;
Biological process	smooth muscle contraction; regulation of ryanodine-sensitive calcium-release channel activity; release of sequestered calcium ion into cytosol; regulation of cardiac conduction; release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; regulation of cytosolic calcium ion concentration; regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; positive regulation of cytosolic calcium ion concentration; cell communication by electrical coupling involved in cardiac conduction; negative regulation of insulin secretion involved in cellular response to glucose stimulus; insulin secretion; response to glucose; positive regulation of axon regeneration; protein maturation by protein folding; response to organic substance; negative regulation of heart rate; response to vitamin E; regulation of heart rate; negative regulation of ryanodine-sensitive calcium-release channel activity; response to redox state; T cell proliferation; ion transmembrane transport; positive regulation of sequestering of calcium ion; neuronal action potential propagation; protein refolding; negative regulation of release of sequestered calcium ion into cytosol; regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; 'de novo' protein folding; calcium-mediated signaling using intracellular calcium source; response to hydrogen peroxide; chaperone-mediated protein folding; protein peptidyl-prolyl isomerization; negative regulation of phosphoprotein phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
	2281
	14226
	ENSG00000119782
	ENSMUSG00000020635
	P68106
	Q9Z2I2
	NM_004116; NM_054033; NM_001322963; NM_001322964
	NM_016863; NM_001378816; NM_001378817; NM_001378818
	NP_001309892; NP_001309893; NP_004107; NP_473374
	NP_058559; NP_001365745; NP_001365746; NP_001365747
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidyl-prolyl cis-trans isomerase FKBP1B is an enzyme that in humans is encoded by the FKBP1B gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000119782 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020635 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Arakawa H, Nagase H, Hayashi N, Fujiwara T, Ogawa M, Shin S, Nakamura Y (Jun 1994). "Molecular cloning and expression of a novel human gene that is highly homologous to human FK506-binding protein 12kDa (hFKBP-12) and characterization of two alternatively spliced transcripts". Biochem Biophys Res Commun. 200 (2): 836–43. doi:10.1006/bbrc.1994.1527. PMID 7513996.
^ "Entrez Gene: FKBP1B FK506 binding protein 1B, 12.6 kDa".

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

References

Further reading