Makari graduated from University of Texas in Austin in Civil engineering and joined Oger Saudi and Oger International, companies founded by the late, former Lebanese Prime Minister Rafik Hariri. In 1992, Makari entered politics, winning the Antiochian Orthodox parliamentary seat in the district of Koura. Makari was re-elected in 1996, 2000, 2005 and 2009. Between 1995-1996, Makari was appointed Information Minister in the Government administration of Rafik Hariri and in 2005, Makari established himself as one of the prominent figures in the Cedar Revolution following Hariri's assassination. The Koura constituents chose to elect Makari to Parliament for a fourth term as part of the majority March 14 bloc and he was appointed Deputy Speaker of Parliament, a position from which Makari has since adopted and espoused many strong political stands. Makari has been since 2005 Vice-President of the Lebanese Parliament.