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Aliases GOSR1, GOLIM2, GOS-28, GOS28, GOS28/P28, GS28, P28, golgi SNAP receptor complex member 1
External IDs MGI: 1858260 HomoloGene: 37977 GeneCards: GOSR1
Gene location (Human)
Chromosome 17 (human)
Chr. Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for GOSR1
Genomic location for GOSR1
Band 17q11.2 Start 30,477,362 bp[1]
End 30,527,592 bp[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 17: 30.48 – 30.53 Mb Chr 17: 76.73 – 76.76 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Golgi SNAP receptor complex member 1 is a protein that in humans is encoded by the GOSR1 gene.[5][6][7][8]

This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi apparatus and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[8]


GOSR1 has been shown to interact with USO1,[9] BET1L[9][10] and STX5.[9][11][12][13]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108587 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000010392 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Subramaniam VN, Peter F, Philp R, Wong SH, Hong W (May 1996). "GS28, a 28-kilodalton Golgi SNARE that participates in ER-Golgi transport". Science. 272 (5265): 1161–3. doi:10.1126/science.272.5265.1161. PMID 8638159. 
  6. ^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Jul 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proceedings of the National Academy of Sciences of the United States of America. 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949Freely accessible. PMID 9653160. 
  7. ^ Oka T, Ungar D, Hughson FM, Krieger M (May 2004). "The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins". Molecular Biology of the Cell. 15 (5): 2423–35. doi:10.1091/mbc.E03-09-0699. PMC 404034Freely accessible. PMID 15004235. 
  8. ^ a b "Entrez Gene: GOSR1 golgi SNAP receptor complex member 1". 
  9. ^ a b c Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (Apr 2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". The Journal of Cell Biology. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270Freely accessible. PMID 11927603. 
  10. ^ Xu Y, Martin S, James DE, Hong W (Oct 2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Molecular Biology of the Cell. 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC 129961Freely accessible. PMID 12388752. 
  11. ^ Hay JC, Chao DS, Kuo CS, Scheller RH (Apr 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. PMID 9094723. 
  12. ^ Hay JC, Klumperman J, Oorschot V, Steegmaier M, Kuo CS, Scheller RH (Jun 1998). "Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs". The Journal of Cell Biology. 141 (7): 1489–502. doi:10.1083/jcb.141.7.1489. PMC 2133002Freely accessible. PMID 9647643. 
  13. ^ Subramaniam VN, Loh E, Hong W (Oct 1997). "N-Ethylmaleimide-sensitive factor (NSF) and alpha-soluble NSF attachment proteins (SNAP) mediate dissociation of GS28-syntaxin 5 Golgi SNAP receptors (SNARE) complex". The Journal of Biological Chemistry. 272 (41): 25441–4. doi:10.1074/jbc.272.41.25441. PMID 9325254. 

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