Glucosamine-phosphate N-acetyltransferase
| glucosamine 6-phosphate N-acetyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.3.1.4 | ||||||||
| CAS no. | 9031-91-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a glucosamine-phosphate N-acetyltransferase (EC 2.3.1.4) is an enzyme that catalyzes the chemical reaction
- acetyl-CoA + D-glucosamine 6-phosphate CoA + N-acetyl-D-glucosamine 6-phosphate
Thus, the two substrates of this enzyme are acetyl-CoA and D-glucosamine 6-phosphate, whereas its two products are CoA and N-acetyl-D-glucosamine 6-phosphate.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups.[1] The systematic name of this enzyme class is acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase. Other names in common use include phosphoglucosamine transacetylase, phosphoglucosamine acetylase, glucosamine-6-phosphate acetylase, D-glucosamine-6-P N-acetyltransferase, aminodeoxyglucosephosphate acetyltransferase, glucosamine 6-phosphate acetylase, glucosamine 6-phosphate N-acetyltransferase, N-acetylglucosamine-6-phosphate synthase, phosphoglucosamine N-acetylase, glucosamine-phosphate N-acetyltransferase, and glucosamine-6-phosphate N-acetyltransferase. This enzyme participates in glutamate metabolism and aminosugars metabolism.
Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1I12, 1I1D, 1I21, 2HUZ, and 2O28.
References
- ^ "Cell-free expression of human Glucosamine 6-phosphate N-acetyltransferase (HsGNA1) for inhibitor screening". Protein Expres Purif. 86 (2): 120–126. 2012. doi:10.1016/j.pep.2012.09.011. PMID 23036358.
{{cite journal}}: Unknown parameter|authors=ignored (help)
- Davidson EA; Blumenthal, HJ; Roseman, S (1966). "Glucosamine 6-phosphate N-acetylase". Methods Enzymol. 9 (1): 704–707. doi:10.1016/0076-6879(66)09142-0.
- DAVIDSON EA, BLUMENTHAL HJ, ROSEMAN S (1957). "Glucosamine metabolism. II. Studies on glucosamine 6-phosphate N-acetylase". J. Biol. Chem. 226 (1): 125–33. PMID 13428743.
- PATTABIRAMAN TN, BACHHAWAT BK (1962). "Purification of glucosamine-6-phosphate N-acetylase from sheep brain". Biochim. Biophys. Acta. 59 (3): 681–9. doi:10.1016/0006-3002(62)90648-0. PMID 14484387.
- Hui CC, Chung S, Huber LA, Mak TW, Iscove NN (2000). "Cloning and characterization of the murine glucosamine-6-phosphate acetyltransferase EMeg32. Differential expression and intracellular membrane association". J. Biol. Chem. 275 (17): 12821–32. doi:10.1074/jbc.275.17.12821. PMID 10777580.
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