Guidepost cells

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Guidepost cells are cells which assist in the subcellular organization of both neural axon growth and migration.[1] These cells are typically other, sometimes immature, neurons and glial cells.[2]


Many types of cells serve as guidepost cells. Guidepost cells are identified by their singular importance in axon guidance of other cells.[3] To qualify as a guidepost cell, neurons hypothesized to be influenced by the guidance cell are examined during development with the guidance cell in question present and missing (either by destroying the cell or through gene knockout).[citation needed]

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  1. ^ Palka, J; John Palka; Kathleen E. Whitlock; Marjorie A. Murray (February 1992). "Guidepost cells". Current Opinion in Neurobiology. 2 (1): 48–54. doi:10.1016/0959-4388(92)90161-D. PMID 1638135. 
  2. ^ Colón-Ramos DA, Shen K, 2008 Cellular Conductors: Glial Cells as Guideposts during Neural Circuit Development. PLoS Biol 6(4): e112. doi:10.1371/journal.pbio.0060112
  3. ^ Bentley, David; Michael Caudy (1983-07-07). "Pioneer axons lose directed growth after selective killing of guidepost cells". Nature. 304 (5921): 62–65. doi:10.1038/304062a0. PMID 6866090. 

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