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Hepatitis A and B vaccine

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Hepatitis A and B vaccine
Combination of
Hepatitis AVaccine
Hepatitis BVaccine
Clinical data
Trade namesTwinrix, Twinrix Adult, AmBirix, Twinrix Jr, Twinrix Paediatric
AHFS/Drugs.comFDA Professional Drug Information
Routes of
administration		Intramuscular injection
ATC code
Identifiers
CAS Number
ChemSpider
  • none

Twinrix is a vaccine against hepatitis A and hepatitis B, manufactured by GlaxoSmithKline. The full generic name is hepatitis A (inactivated) and hepatitis B (rDNA) (HAB) vaccine (adsorbed). Twinrix is administered over three doses.

The name was created because it is a mixture of two earlier vaccines — Havrix, an inactivated-virus Hepatitis A vaccine, and Engerix-B, a recombinant Hepatitis B vaccine. Twinrix, Havrix and Engerix-B are registered trademarks of GlaxoSmithKline. Twinrix first entered the market in early 1997.[citation needed]

In some countries outside the USA, notably Canada and Europe, Twinrix is known as Twinrix Adult or AmBirix and a pediatric formulation, called Twinrix Jr or Twinrix Paediatric, is available.

Administration schedule

Twinrix can be administered on the same schedule as monovalent Hepatitis B vaccine: at 0- 1- and 6- months. In some circumstances, an accelerated dosing schedule of 0- 7- and 21-to 30- days followed by a booster at 12 months can be used and is believed to have similar efficacy as the traditional schedule.[1]

Efficacy

The CDC reports that clinical trials found the following levels of protection against Hep A and Hep B one month after each dose:[2]

A: 93.8%, 98.8%, 99.9%
B: 30.8%, 78.2%, 98.5%

GlaxoSmithKline claims that its studies found 70% of subjects had antibodies against hepatitis B a month after just the first dose, however.[3]

See also

References

  1. ^ http://us.gsk.com/products/assets/us_twinrix.pdf
  2. ^ "FDA approval for a combined hepatitis A and B vaccine". MMWR Morb. Mortal. Wkly. Rep. 50 (37): 806–7. September 2001. PMID 11785573.
  3. ^ Twinrix Adult Vaccine, SPC from the eMC


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