HuD (protein)

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Available structures
PDBOrtholog search: PDBe RCSB
AliasesELAVL4, HUD, PNEM, HuD, ELAV like neuron-specific RNA binding protein 4, ELAV like RNA binding protein 4
External IDsMGI: 107427 HomoloGene: 40729 GeneCards: ELAVL4
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ELAVL4
Genomic location for ELAVL4
Band1p33-p32.3Start50,048,014 bp[1]
End50,203,786 bp[1]
RNA expression pattern
PBB GE ELAVL4 206051 at fs.png
More reference expression data
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 1: 50.05 – 50.2 MbChr 4: 110.2 – 110.35 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

HuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ELAVL4 gene.[5][6]

The HuD/ELAVL4 protein is an RNA-binding protein.[7] HuD contains three RRM protein domains, enabling RNA binding.[8]

HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity.[9][10]


HuD (protein) has been shown to interact with NXF1.[11]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162374 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028546 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Muresu R, Baldini A, Gress T, Posner JB, Furneaux HM, Siniscalco M (Dec 1993). "Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34". Cytogenet Cell Genet. 65 (3): 177–8. doi:10.1159/000133626. PMID 8222755.
  6. ^ "Entrez Gene: ELAVL4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)".
  7. ^ Szabo A, Dalmau J, Manley G, et al. (1991). "HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal". Cell. 67 (2): 325–33. doi:10.1016/0092-8674(91)90184-Z. PMID 1655278.
  8. ^ "RNA-binding proteins in human genetic disease". Trends in Genetics. 24 (8): 416–425. 2008-08-01. doi:10.1016/j.tig.2008.05.004. ISSN 0168-9525.
  9. ^ Nora Perrone-Bizzozero; Federico Bolognani (2002). "Role of HuD and other RNA-binding proteins in neural development and plasticity". J Neurosci Res. 68 (2): 121–126. doi:10.1002/jnr.10175. PMID 11948657.
  10. ^ Federico Bolognani; Nora Perrone-Bizzozero (2008). "RNA-protein interactions and control of mRNA stability in neurons". J Neurosci Res. 86 (3): 481–489. doi:10.1002/jnr.21473. PMID 17853436.
  11. ^ Saito, Kuniaki; Fujiwara Toshinobu; Katahira Jun; Inoue Kunio; Sakamoto Hiroshi (Aug 2004). "TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD". Biochem. Biophys. Res. Commun. United States. 321 (2): 291–7. doi:10.1016/j.bbrc.2004.06.140. ISSN 0006-291X. PMID 15358174.

Further reading[edit]