Isoquinoline 1-oxidoreductase

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isoquinoline 1-oxidoreductase
EC number
CAS number 155948-73-5
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, an isoquinoline 1-oxidoreductase (EC is an enzyme that catalyzes the chemical reaction

isoquinoline + acceptor + H2O isoquinolin-1(2H)-one + reduced acceptor

The 3 substrates of this enzyme are isoquinoline, acceptor, and H2O, whereas its two products are isoquinolin-1(2H)-one and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is isoquinoline:acceptor 1-oxidoreductase (hydroxylating).


  • Lehmann M, Tshisuaka B, Fetzner S, Roger P, Lingens F (1994). "Purification and characterization of isoquinoline 1-oxidoreductase from Pseudomonas diminuta 7, a novel molybdenum-containing hydroxylase". J. Biol. Chem. 269 (15): 11254–60. PMID 8157655. 
  • Lehmann M, Tshisuaka B, Fetzner S, Lingens F (1995). "Molecular cloning of the isoquinoline 1-oxidoreductase genes from Pseudomonas diminuta 7, structural analysis of iorA and iorB, and sequence comparisons with other molybdenum-containing hydroxylases". J. Biol. Chem. 270 (24): 14420–9. PMID 7782304. doi:10.1074/jbc.270.24.14420.