KIF1C

KIF1C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2G1L
Identifiers
Aliases	KIF1C, LTXS1, SATX2, SAX2, SPAX2, SPG58, kinesin family member 1C
External IDs	OMIM: 603060; MGI: 1098260; HomoloGene: 4821; GeneCards: KIF1C; OMA:KIF1C - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	5,028,401 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	70,731,964 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; gastrocnemius muscle; ; muscle of thigh; ; apex of heart; ; left ventricle; ; right auricle; ; Skeletal muscle tissue of rectus abdominis; ; amygdala; ; olfactory bulb; ; Descending thoracic aorta;
	Top expressed in
	muscle of thigh; ; triceps brachii muscle; ; digastric muscle; ; vastus lateralis muscle; ; gastrocnemius muscle; ; myocardium of ventricle; ; sternocleidomastoid muscle; ; lip; ; ankle; ; ankle joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	microtubule binding; microtubule motor activity; nucleotide binding; ATPase activity; cytoskeletal motor activity; protein binding; ATP binding; RNA binding; plus-end-directed microtubule motor activity;
Cellular component	cytoplasm; Golgi apparatus; microtubule; cytoskeleton; endoplasmic reticulum; kinesin complex; axon; dendrite; neuron projection; axon cytoplasm;
Biological process	cytoskeleton-dependent intracellular transport; microtubule-based movement; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; vesicle-mediated transport; anterograde neuronal dense core vesicle transport; retrograde neuronal dense core vesicle transport;
	Sources:Amigo / QuickGO
Orthologs
	10749
	16562
	ENSG00000129250
	ENSMUSG00000020821
	O43896
	O35071
	NM_006612
	NM_153103
	NP_006603
	NP_694743
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin-like protein KIF1C is a protein that in humans is encoded by the KIF1C gene.^[5]^[6] Kif1C is a fast, non-processive, plus-end directed microtubule motor.^[7] Kif1C transports α5β1-integrins in human cells.^[8] Kif1C has been shown to be non-essential in mouse with other proteins able to perform the same function.^[9]

Interactions

KIF1C has been shown to interact with PTPN21^[5] and YWHAG.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000129250 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020821 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Dorner C, Ciossek T, Muller S, Moller PH, Ullrich A, Lammers R (September 1998). "Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum". J Biol Chem. 273 (32): 20267–75. doi:10.1074/jbc.273.32.20267. PMID 9685376.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: KIF1C kinesin family member 1C".
^ Rogers KR, Weiss S, Crevel I, Brophy PJ, Geeves M, Cross R (September 2001). "KIF1D is a fast non-processive kinesin that demonstrates novel K-loop-dependent mechanochemistry". EMBO J. 20 (18): 5101–13. doi:10.1093/emboj/20.18.5101. PMC 125638. PMID 11566875.
^ Theisen U, Straube E, Straube A (December 2012). "Directional persistence of migrating cells requires Kif1C-mediated stabilization of trailing adhesions". Dev. Cell. 23 (6): 1153–66. doi:10.1016/j.devcel.2012.11.005. PMID 23237952.
^ Kazuo N, Yosuke T, Yosuke T, Terunaga N, Takao N, Yasuko N, Mitsutoshi S, Nobutaka H (February 2002). "Molecular Motor KIF1C Is Not Essential for Mouse Survival and Motor-Dependent Retrograde Golgi Apparatus-to-Endoplasmic Reticulum Transport". Molecular and Cell Biology. 38 (13): 866–873. doi:10.1128/MCB.22.3.866-873.2002. PMC 133549.
^ Dorner C, Ullrich A, Häring HU, Lammers R (November 1999). "The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family". J. Biol. Chem. 274 (47): 33654–60. doi:10.1074/jbc.274.47.33654. PMID 10559254.{{cite journal}}: CS1 maint: unflagged free DOI (link)

Ishikawa K; Nagase T; Suyama M; et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Dorner C, Ullrich A, Häring HU, Lammers R (1999). "The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family". J. Biol. Chem. 274 (47): 33654–60. doi:10.1074/jbc.274.47.33654. PMID 10559254.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Rual JF; Venkatesan K; Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Kopp P; Lammers R; Aepfelbacher M; et al. (2006). "The Kinesin KIF1C and Microtubule Plus Ends Regulate Podosome Dynamics in Macrophages". Mol. Biol. Cell. 17 (6): 2811–23. doi:10.1091/mbc.E05-11-1010. PMC 1474789. PMID 16554367. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Beausoleil SA; Villén J; Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Olsen JV; Blagoev B; Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000129250 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020821 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9685376-5] Dorner C, Ciossek T, Muller S, Moller PH, Ullrich A, Lammers R (September 1998). "Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum". J Biol Chem. 273 (32): 20267–75. doi:10.1074/jbc.273.32.20267. PMID 9685376.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[entrez-6] "Entrez Gene: KIF1C kinesin family member 1C".

[pmid11566875-7] Rogers KR, Weiss S, Crevel I, Brophy PJ, Geeves M, Cross R (September 2001). "KIF1D is a fast non-processive kinesin that demonstrates novel K-loop-dependent mechanochemistry". EMBO J. 20 (18): 5101–13. doi:10.1093/emboj/20.18.5101. PMC 125638. PMID 11566875.

[pmid23237952-8] Theisen U, Straube E, Straube A (December 2012). "Directional persistence of migrating cells requires Kif1C-mediated stabilization of trailing adhesions". Dev. Cell. 23 (6): 1153–66. doi:10.1016/j.devcel.2012.11.005. PMID 23237952.

[9] Kazuo N, Yosuke T, Yosuke T, Terunaga N, Takao N, Yasuko N, Mitsutoshi S, Nobutaka H (February 2002). "Molecular Motor KIF1C Is Not Essential for Mouse Survival and Motor-Dependent Retrograde Golgi Apparatus-to-Endoplasmic Reticulum Transport". Molecular and Cell Biology. 38 (13): 866–873. doi:10.1128/MCB.22.3.866-873.2002. PMC 133549.

[pmid10559254-10] Dorner C, Ullrich A, Häring HU, Lammers R (November 1999). "The kinesin-like motor protein KIF1C occurs in intact cells as a dimer and associates with proteins of the 14-3-3 family". J. Biol. Chem. 274 (47): 33654–60. doi:10.1074/jbc.274.47.33654. PMID 10559254.{{cite journal}}: CS1 maint: unflagged free DOI (link)

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Interactions

References

Further reading