MAFA (gene)

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MAFA[edit]

Transcription factor MafA is a protein that in humans is encoded by the MAFA gene.[1] It is a member of the Maf family of transcription factors. [2]

MAFA Assists in Insulin Regulation[edit]

An in vivo study on mice proved MafA binds to the promoter in an insulin gene to regulate insulin transcription in response to serum glucose levels.[3] MafA is a β cell-specific activator, which differentiates it from other transcription factors involved with insulin gene expression.[4] It helps regulate the β cells involved with insulin secretion primarily by maintaining β cell metabolism.[5] The amount of MafA in the β cells is regulated by levels of glucose and oxidative stress.[2]

MAFA
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases MAFA, RIPE3b1, hMafA, MAF bZIP transcription factor A
External IDs MGI: 2673307 HomoloGene: 65867 GeneCards: MAFA
RNA expression pattern
PBB GE MAFA gnf1h10761 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_201589

NM_194350

RefSeq (protein)

NP_963883

NP_919331.1
NP_919331

Location (UCSC) Chr 8: 143.42 – 143.43 Mb Chr 15: 75.75 – 75.75 Mb
PubMed search [6] [7]
Wikidata
View/Edit Human View/Edit Mouse


Interactions[edit]

MafA (gene) has been shown to interact with NEUROD1[8] and Pdx1.[8] MafA works with Pdx1 to activate the insulin gene. [2]

References[edit]

  1. ^ "Entrez Gene: MAFA v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)". 
  2. ^ a b c Aramata; Han. "Roles and Regulation of Transcription Factor MafA in Islet β-cells". Endocr. J. 54: 659–66. doi:10.1507/endocrj.kr-101. PMID 17785922. 
  3. ^ Zhang; Moriguchi. "MafA Is a Key Regulator of Glucose-Stimulated Insulin Secretion". Mol. Cell. Biol. 25: 4969–4976. doi:10.1128/MCB.25.12.4969-4976.2005. PMC 1140590Freely accessible. PMID 15923615. 
  4. ^ Matsuoka; Artner (March 2004). "The MafA transcription factor appears to be responsible for tissue-specific expression of insulin". Proc. Natl. Acad. Sci. U.S.A. 101: 2930–3. doi:10.1073/pnas.0306233101. PMC 365722Freely accessible. PMID 14973194. 
  5. ^ Wang; Kataoka (2007). "MAFA controls genes implicated in insulin biosynthesis and secretion.". Diabetologia. 50: 348–58. doi:10.1007/s00125-006-0490-2. PMC 2196442Freely accessible. PMID 17149590. 
  6. ^ "Human PubMed Reference:". 
  7. ^ "Mouse PubMed Reference:". 
  8. ^ a b Zhao, Li; Guo Min; Matsuoka Taka-Aki; Hagman Derek K; Parazzoli Susan D; Poitout Vincent; Stein Roland (Mar 2005). "The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription". J. Biol. Chem. United States. 280 (12): 11887–94. doi:10.1074/jbc.M409475200. ISSN 0021-9258. PMID 15665000. 

Further reading[edit]