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Available structures
PDBOrtholog search: PDBe RCSB
AliasesNEUROD1, BETA2, BHF-1, MODY6, NEUROD, bHLHa3, neuronal differentiation 1, T2D
External IDsOMIM: 601724 MGI: 1339708 HomoloGene: 1871 GeneCards: NEUROD1
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 2: 181.67 – 181.68 MbChr 2: 79.28 – 79.29 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Neurogenic differentiation 1 (NeuroD1), also called β2,[5] is a transcription factor of the NeuroD-type. It is encoded by the human gene NEUROD1.

It is a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus.[6]

NeuroD1 is found to convert reactive glial cells into functional neurons in the mouse brain in vivo[7]


NEUROD1 has been shown to interact with MAP3K10,[8] MAFA[9] and Cyclin D1.[10]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162992 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034701 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Poulin G, Turgeon B, Drouin J (November 1997). "NeuroD1/beta2 contributes to cell-specific transcription of the proopiomelanocortin gene". Molecular and Cellular Biology. 17 (11): 6673–82. doi:10.1128/mcb.17.11.6673. PMC 232521. PMID 9343431.
  6. ^ "Entrez Gene: NEUROD1 neurogenic differentiation 1".
  7. ^ Guo Z, Zhang L, Wu Z, Chen Y, Wang F, Chen G (February 2014). "In vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model". Cell Stem Cell. 14 (2): 188–202. doi:10.1016/j.stem.2013.12.001. PMC 3967760. PMID 24360883.
  8. ^ Marcora E, Gowan K, Lee JE (August 2003). "Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2". Proceedings of the National Academy of Sciences of the United States of America. 100 (16): 9578–83. Bibcode:2003PNAS..100.9578M. doi:10.1073/pnas.1133382100. PMC 170960. PMID 12881483.
  9. ^ Zhao L, Guo M, Matsuoka TA, Hagman DK, Parazzoli SD, Poitout V, Stein R (March 2005). "The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription". The Journal of Biological Chemistry. 280 (12): 11887–94. doi:10.1074/jbc.M409475200. PMID 15665000.
  10. ^ Ratineau C, Petry MW, Mutoh H, Leiter AB (March 2002). "Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD". The Journal of Biological Chemistry. 277 (11): 8847–53. doi:10.1074/jbc.M110747200. PMID 11788592.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.