Marasmus

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Marasmus
Starved child.jpg
Child suffering with Marasmus in Nepal, 1972
Classification and external resources
Specialty Critical care medicine
ICD-10 E41-E42
ICD-9-CM 261
DiseasesDB 7826
eMedicine ped/164
MeSH D011502

Marasmus is a form of severe malnutrition characterized by protein deficiency.It can occur in anyone with severe malnutrition but usually occurs in children.[1] A child with marasmus looks emaciated. Body weight is reduced to less than 62.36% of the normal (expected) body weight for the age.[2] Marasmus occurrence increases prior to age 1, whereas kwashiorkor occurrence increases after 18 months. It can be distinguished from kwashiorkor in that kwashiorkor is protein deficiency with adequate energy intake whereas marasmus is inadequate energy intake in all forms, including protein. This clear-cut separation of marasmus and kwashiorkor is however not always clinically evident as kwashiorkor is often seen in a context of insufficient caloric intake, and mixed clinical pictures, called marasmic kwashiorkor, are possible. Protein wasting in kwashiorkor generally leads to edema and ascites, while muscular wasting and loss of subcutaneous fat are the main clinical signs of marasmus.[citation needed]

The prognosis is better than it is for kwashiorkor[3] but half of severely malnourished children die due to unavailability of adequate treatment.[citation needed]

The word “marasmus” comes from the Greek μαρασμός marasmos ("withering").

Signs and symptoms[edit]

Buchenwald inmates, 16 April 1945 when camp was liberated

Marasmus is commonly represented by a shrunken, wasted appearance, loss of muscle mass and subcutaneous fat mass.[4] Buttocks and upper limb muscle groups are usually more affected than others. Edema is not a sign of marasmus and is only present in kwashiorkor, and marasmic kwashiorkor. Other symptoms of marasmus include unusual body temperature (hypothermia, pyrexia), anemia, dehydration (as characterized with consistent thirst and shrunken eyes), hypovolemic shock (weak radial pulse, cold extremities, decreased consciousness), tachypnea (pneumonia, heart failure), abdominal manifestations (distension, decreased or metallic bowel sounds, large or small liver, blood or mucus in the stools), ocular manifestations (corneal lesions associated with vitamin A deficiency), dermal manifestations (evidence of infection, purpura, and ear, nose, and throat symptoms (otitis, rhinitis).[citation needed].Dry skin and brittle hair are also symptoms of marasmus.Marasmus can also make children short-tempered and irritable.[5]

Causes[edit]

Marasmus is caused by a severe deficiency of nearly all nutrients, especially protein, carbohydrates, and lipids.This is usually due to poverty and scarcity of food.[6]

Viral, bacterial, and parasitic infections can cause children to take in too few nutrients.[7] Marasmus can develop in children who suffer from weakening conditions such as chronic diarrhea.[8]

Treatment[edit]

It is necessary to treat not only the causes but also the complications of the disorder, including infections, dehydration, and circulation disorders, which are frequently lethal and lead to high mortality if ignored.[citation needed]

Initially the child is given dried skim milk powder mixed with boiled water which is then followed by mixing it with vegetable oils and finally sugar.Once a child starts to recover they should have more balanced diet which meets their nutritional needs.Infections are also common in children with marasmus. So they are also treated with antibiotics.[9]

Ultimately, marasmus can progress to the point of no return when the body's ability for protein synthesis is lost. At this point, attempts to correct the disorder by giving food or protein are futile.[citation needed]

Epidemiology[edit]

Persons in prisons, concentration camps, and refugee camps tend to suffer from marasmus, due to poor nutrition.

Disability-adjusted life year for protein-energy malnutrition per 100,000 inhabitants in 2002.[10]
  no data
  less than 10
  10–100
  100–200
  200–300
  300–400
  400–500
  500–600
  600–700
  700–800
  800–1000
  1000–1350
  more than 1350

See also[edit]

References[edit]

  1. ^ "What You Should Know About Marasmus". Healthline. 
  2. ^ Appleton & Vanbergen, Metabolism and Nutrition, Medicine Crash Course 4th ed. Moseby (London: 2013) p.130
  3. ^ Badaloo AV, Forrester T, Reid M, Jahoor F (June 2006). "Lipid kinetic differences between children with kwashiorkor and those with marasmus". Am. J. Clin. Nutr. 83 (6): 1283–8. PMID 16762938. 
  4. ^ Rabinowitz, Simon. "MD, PhD, FAAP". Emedicine Medscape. Medscape. p. 28. Retrieved 29 January 2015. 
  5. ^ "What You Should Know About Marasmus". Healthline. 
  6. ^ "What You Should Know About Marasmus". Healthline. 
  7. ^ http://www.healthline.com/health/marasmus
  8. ^ http://www.healthofchildren.com/P/Protein-Energy-Malnutrition.html
  9. ^ "What You Should Know About Marasmus". Healthline. 
  10. ^ "Mortality and Burden of Disease Estimates for WHO Member States in 2002" (xls). World Health Organization. 2002.