|Other names||ICD10 = E50.1|
|Typical location of Bitot's spots|
Bitot's spots are the buildup of keratin located superficially in the conjunctiva of human's eyes. They can be oval, triangular or irregular in shape. The spots are a sign of vitamin A deficiency and associated with drying of the cornea. In 1863, the French physician Pierre Bitot (1822-1888) first described these spots. The spots may abate under replacement therapy. In ancient Egypt, this was treated with animal liver, which is where vitamin A is stored.
VAD is commonly treated with oral vitamin A supplements. Improvement of Bitot’s spots is seen with high-dose vitamin A therapy. Bitot's spots non-responsive to vitamin A therapy may be removed surgically.
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