During his early career as a painter, he won the 1970 Prize from Villa Romana and the 1971 "German Association of Critics Prize."
As a writer, he has been editing his own journal since 2003, called Frau und Hund of which two editions in other languages have appeared (Signora e cane, in Italian, and Femme et Chien, in French).
In 2011, Lüpertz exhibited a new body of work entitled Pastoral Thoughts at the Michael Werner gallery in New York City. According to the brochure, these are "New works by the celebrated and controversial German artist [which] explore themes of history and abstraction in paintings derived from landscape motifs." The exhibition was labeled: "is the artist’s first major New York showing since 2005," and was accompanied by a fully illustrated catalogue.