N-methylhydantoinase (ATP-hydrolysing)

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N-methylhydantoinase (ATP-hydrolyzing)
EC no.
CAS no.100785-00-0
IntEnzIntEnz view
ExPASyNiceZyme view
MetaCycmetabolic pathway
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a N-methylhydantoinase (ATP-hydrolysing) (EC is an enzyme that catalyzes the chemical reaction[1]

ATP + N-methylimidazolidine-2,4-dione + 2 H2O ADP + phosphate + N-carbamoylsarcosine

The 3 substrates of this enzyme are ATP, N-methylimidazolidine-2,4-dione, and H2O, whereas its 3 products are ADP, phosphate, and N-carbamoylsarcosine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is N-methylimidazolidine-2,4-dione amidohydrolase (ATP-hydrolysing). Other names in common use include N-methylhydantoin amidohydrolase, methylhydantoin amidase, N-methylhydantoin hydrolase, and N-methylhydantoinase. This enzyme participates in arginine, creatinine, and proline metabolism.


  1. ^ Nucleoside triphosphate-dependent 1-methylhydantoinase, a process for obtaining it and the use - United States Patent 4816393. Inventors: Siedel Joachim, Deeg Rolf, Roder Albert, Ziegenhorn Joachim, Mollering Hans, Gauhl Helmgard. Assignee: Boehringer Mannheim. Application Date: 1985-02-25. Publication Date: 1989-03-28.
  • Kim JM, Shimizu S, Yamada H (1987). "Amidohydrolysis of N-methylhydantoin coupled with ATP hydrolysis". Biochem. Biophys. Res. Commun. 142 (3): 1006–12. doi:10.1016/0006-291X(87)91514-2. PMID 3827889.