Jump to content

Nucleoporin 54

From Wikipedia, the free encyclopedia
(Redirected from NUP54)
NUP54
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNUP54, nucleoporin 54
External IDsOMIM: 607607; MGI: 1920460; HomoloGene: 41169; GeneCards: NUP54; OMA:NUP54 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278603
NM_017426

NM_183392
NM_001359995

RefSeq (protein)

NP_001265532
NP_059122

NP_899248
NP_001346924

Location (UCSC)Chr 4: 76.11 – 76.15 MbChr 5: 92.56 – 92.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleoporin 54 (Nup54) is a protein that in humans is encoded by the NUP54 gene.[5][6]

Function

[edit]

The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset.[6]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138750Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034826Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hu T, Guan T, Gerace L (Sep 1996). "Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteins". J Cell Biol. 134 (3): 589–601. doi:10.1083/jcb.134.3.589. PMC 2120945. PMID 8707840.
  6. ^ a b "Entrez Gene: NUP54 nucleoporin 54kDa".

Further reading

[edit]
[edit]
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Nucleoporin p54