Structure of the neoflavonoids backbone (neoflavan represented)
Neoflavonoids are a class of polyphenolic compounds. While  flavonoids (in the narrow sense) have the 2-phenylchromen-4-one backbone, neoflavonoids have the 4-phenylchromen backbone with no hydroxyl group substitution at position 2.
Chemical structure of 4-phenylcoumarin (neoflavone backbone).
Neoflavonoids include 4-arylcoumarins (neoflavones), 4-arylchromanes, dalbergiones and dalbergiquinols.
Neoflavones are derived from the 4-phenylcoumarin (or 4-Aryl-  coumarin) backbone (C 15H 12O 2, molar mass : 224.25g/mol, exact mass : 224.083729). The first neoflavone isolated from natural sources was  calophyllolide from seeds (1951). Calophyllum inophyllum It is also known to found in bark and timber of Sri Lankan endemic plant  . Mesua thwaitesii 
Neoflavenes possess the 4-phenylchromen backbone (chemical formula : C 15H 10O 2, exact mass : 222.0680792). Dalbergichromene, extracted from the stem-bark and heartwood of , is an example of such compounds Dalbergia sissoo 
Other examples [ edit ]
References [ edit ]
^ The neoflavanoids, a new class of natural products. Cellular and Molecular Life Sciences, Volume 22, Number 12 / december 1966
^ Revised structure of neoflavone in Coutarea hexandra. Munekazu Iinuma, Toshiyuki Tanaka, Koji Hamada, Mizuo Mizuno, Fujio Asai, Gesa Reher and Ljubomir Kraus, Phytochemistry, Volume 26, Issue 11, 1987, Pages 3096-3097.
^ Structures of 4-Aryl-coumarin (Neoflavone) Dimers Isolated from Pistacia chinensis BUNGE and Their Estrogen-like Activity. Satoshi NISHIMURA, Motohiko TAKI, Sachiko TAKAISHI, Yasuteru IIJIMA and Toshiyuki AKIYAMA, Chem. Pharm. Bull. 48(4) 505—508 (2000)
^ Neoflavones. 1. Natural Distribution and Spectral and Biological Properties. M. M. Garazd, Ya. L. Garazd and V. P. Khilya, Chemistry of Natural Compounds, Volume 39, Number 1 / janvier 2003.
^ Xanthones and 4-phenylcoumarins of Mesua thwaitesii from bark, timber and seeds.
^ Dalbergichromene : A new neoflavonoid from stem-bark and heartwood of Dalbergia sissoo. Mukerjee S. K., Saroja T. and SeshadriT. R., Tetrahedron, Volume 27, Issue 4, 1971, Pages 799-803
^ Effects of the neoflavonoid coutareagenin, one of the antidiabetic active substances of Hintonia latiflora, on streptozotocin-induced diabetes mellitus in rats. Korec R., Sensch K. H., Zoukas T., Symposium der Paul-Martini-Stiftung in Verbindung mit der Akademie der Wissenschaften und der Literatur, Mainz, Germany (12/11/1999) 2000, vol. 50, no 2, pp. 189-224 (33 ref.), pp. 122-128
^ Nivetin, a neoflavonoid from Echinops niveus. Singh P. and Pandey V.B., Phytochemistry, Volume 29, Issue 2, 1990, Pages 680-681
External links [ edit ]