Nicotinate N-methyltransferase
| nicotinate N-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 HhaI methyltransferase monomer + DNA fragment, Haemophilus haemolyticus | |||||||||
| Identifiers | |||||||||
| EC no. | 2.1.1.7 | ||||||||
| CAS no. | 9029-79-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a nicotinate N-methyltransferase (EC 2.1.1.7) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + nicotinate S-adenosyl-L-homocysteine + N-methylnicotinate
Thus, the two substrates of this enzyme are S-adenosyl methionine and nicotinate, whereas its two products are S-adenosylhomocysteine and N-methylnicotinate.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:nicotinate N-methyltransferase. Other names in common use include furanocoumarin 8-methyltransferase, and furanocoumarin 8-O-methyltransferase. This enzyme participates in nicotinate and nicotinamide metabolism.
Structural studies
[edit]As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 5MHT.
References
[edit]- Joshi JG, Handler P (1960). "Biosynthesis of trigonelline". J. Biol. Chem. 235 (10): 2981–2983. doi:10.1016/S0021-9258(18)64575-2. PMID 13790768.
