OSTalpha

SLC51A
Identifiers
Aliases	SLC51A, OSTA, OSTalpha, solute carrier family 51 alpha subunit, solute carrier family 51 subunit alpha, PFIC6
External IDs	OMIM: 612084; MGI: 2146634; HomoloGene: 44941; GeneCards: SLC51A; OMA:SLC51A - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	196,243,178 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	32,306,697 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; jejunal mucosa; ; duodenum; ; sperm; ; right adrenal gland; ; palpebral conjunctiva; ; bone marrow cells; ; gastrocnemius muscle; ; skin of abdomen; ; right uterine tube;
	Top expressed in
	ileum; ; intestinal villus; ; jejunum; ; duodenum; ; kidney; ; proximal tubule; ; crypt of lieberkuhn of small intestine; ; yolk sac; ; Paneth cell; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein homodimerization activity; protein heterodimerization activity; bile acid transmembrane transporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; basolateral plasma membrane; protein-containing complex;
Biological process	bile acid and bile salt transport; bile acid secretion; transmembrane transport; organic substance transport;
	Sources:Amigo / QuickGO
Orthologs
	200931
	106407
	ENSG00000163959
	ENSMUSG00000035699
	Q86UW1
	Q8R000
	NM_152672
	NM_145932
	NP_689885
	NP_666044
	Wikidata
View/Edit Human	View/Edit Mouse

Organic solute transporter alpha, also known as OST-alpha, is a protein which in humans is encoded by the OSTA gene.^[5]^[6]

Function

OST-alpha together with OST-beta is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes.^[6]^[7] The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake.^[7] The heterodimer furthermore is essential for intestinal bile acid transport.^[8]

OST-alpha and OST-alpha have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163959 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035699 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: OSTalpha organic solute transporter alpha".
^ ^a ^b ^c Seward DJ, Koh AS, Boyer JL, Ballatori N (July 2003). "Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta". J. Biol. Chem. 278 (30): 27473–82. doi:10.1074/jbc.M301106200. PMID 12719432.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ ^a ^b Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N (February 2005). "The Heteromeric Organic Solute Transporter α-β, Ostα-Ostβ, Is an Ileal Basolateral Bile Acid Transporter". J. Biol. Chem. 280 (8): 6960–8. doi:10.1074/jbc.M412752200. PMC 1224727. PMID 15563450.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA (March 2008). "The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis". Proc. Natl. Acad. Sci. U.S.A. 105 (10): 3891–6. doi:10.1073/pnas.0712328105. PMC 2268840. PMID 18292224.

OSTalpha

Function

See also

References

Further reading