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PCDH18

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(Redirected from PCDH18 (gene))
PCDH18
Identifiers
AliasesPCDH18, PCDH68L, protocadherin 18
External IDsOMIM: 608287; MGI: 1920423; HomoloGene: 10389; GeneCards: PCDH18; OMA:PCDH18 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001300828
NM_019035

NM_130448

RefSeq (protein)

NP_001287757
NP_061908

Location (UCSC)Chr 4: 137.52 – 137.53 MbChr 3: 49.7 – 49.71 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protocadherin-18 is a protein that in humans is encoded by the PCDH18 gene.[5][6][7]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000189184Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037892Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
  6. ^ Wolverton T, Lalande M (Sep 2001). "Identification and characterization of three members of a novel subclass of protocadherins". Genomics. 76 (1–3): 66–72. doi:10.1006/geno.2001.6592. PMID 11549318.
  7. ^ a b "Entrez Gene: PCDH18 protocadherin 18".

Further reading

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