POLR2L

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POLR2L
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases POLR2L, RBP10, RPABC5, RPB10, RPB10beta, RPB7.6, hRPB7.6, polymerase (RNA) II subunit L
External IDs MGI: 1913741 HomoloGene: 129854 GeneCards: POLR2L
RNA expression pattern
PBB GE POLR2L 211730 s at fs.png

PBB GE POLR2L 202586 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021128

NM_025593

RefSeq (protein)

NP_066951

NP_079869.1
NP_079869

Location (UCSC) Chr 11: 0.84 – 0.84 Mb Chr 7: 141.47 – 141.48 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

DNA-directed RNA polymerases I, II, and III subunit RPABC5 is a protein that in humans is encoded by the POLR2L gene.[3]

Function[edit]

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases.[4]

Interactions[edit]

POLR2L has been shown to interact with POLR2C,[5] POLR2A,[5] POLR2B[5] and POLR2E.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Acker J, Murroni O, Mattei MG, Kedinger C, Vigneron M (September 1996). "The gene (POLR2L) encoding the hRPB7.6 subunit of human RNA polymerase". Genomics. 32 (1): 86–90. doi:10.1006/geno.1996.0079. PMID 8786124. 
  4. ^ "Entrez Gene: POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa". 
  5. ^ a b c d Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. PMID 9201987. 

Further reading[edit]